Human herpesvirus 6 viremia in bone marrow transplant recipients: Clinical features and risk factors

Tetsushi Yoshikawa, Yoshizo Asano, Masaru Ihira, Kyoko Suzuki, Masahiro Ohashi, Sadao Suga, Kazuko Kudo, Keizo Horibe, Seiji Kojima, Koji Kato, Takaharu Matsuyama, Yukihiro Nishiyama

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Abstract

Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P = .011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n = 72). Geometric mean antibody titers (log10) were significantly higher in recipients without viremia than in those with viremia (1.84 ± 0.39 vs. 1.61 ± 0.42; P = .022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P = .031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P = .001).

Original languageEnglish
Pages (from-to)847-853
Number of pages7
JournalJournal of Infectious Diseases
Volume185
Issue number7
DOIs
Publication statusPublished - 01-04-2002

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Yoshikawa, T., Asano, Y., Ihira, M., Suzuki, K., Ohashi, M., Suga, S., Kudo, K., Horibe, K., Kojima, S., Kato, K., Matsuyama, T., & Nishiyama, Y. (2002). Human herpesvirus 6 viremia in bone marrow transplant recipients: Clinical features and risk factors. Journal of Infectious Diseases, 185(7), 847-853. https://doi.org/10.1086/339411