Human herpesvirus 6 viremia in bone marrow transplant recipients: Clinical features and risk factors

Tetsushi Yoshikawa, Yoshizo Asano, Masaru Ihira, Kyoko Suzuki, Masahiro Ohashi, Sadao Suga, Kazuko Kudo, Keizo Horibe, Seiji Kojima, Koji Kato, Takaharu Matsuyama, Yukihiro Nishiyama

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Abstract

Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P = .011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n = 72). Geometric mean antibody titers (log10) were significantly higher in recipients without viremia than in those with viremia (1.84 ± 0.39 vs. 1.61 ± 0.42; P = .022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P = .031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P = .001).

Original languageEnglish
Pages (from-to)847-853
Number of pages7
JournalJournal of Infectious Diseases
Volume185
Issue number7
DOIs
Publication statusPublished - 01-04-2002

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Human Herpesvirus 6
Viremia
Bone Marrow
Transplantation
Herpesviridae Infections
Antibodies
Transplant Recipients
Exanthema
Bone Marrow Transplantation
Lymphoma
Leukemia
Logistic Models
Regression Analysis
Tissue Donors
Incidence

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Yoshikawa, Tetsushi ; Asano, Yoshizo ; Ihira, Masaru ; Suzuki, Kyoko ; Ohashi, Masahiro ; Suga, Sadao ; Kudo, Kazuko ; Horibe, Keizo ; Kojima, Seiji ; Kato, Koji ; Matsuyama, Takaharu ; Nishiyama, Yukihiro. / Human herpesvirus 6 viremia in bone marrow transplant recipients : Clinical features and risk factors. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. 7. pp. 847-853.
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abstract = "Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8{\%}) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P = .011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n = 72). Geometric mean antibody titers (log10) were significantly higher in recipients without viremia than in those with viremia (1.84 ± 0.39 vs. 1.61 ± 0.42; P = .022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P = .031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8{\%}) of 31 recipients with HHV-6 viremia but in only 8 (19.5{\%}) of 41 recipients without HHV-6 viremia (P = .001).",
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Yoshikawa, T, Asano, Y, Ihira, M, Suzuki, K, Ohashi, M, Suga, S, Kudo, K, Horibe, K, Kojima, S, Kato, K, Matsuyama, T & Nishiyama, Y 2002, 'Human herpesvirus 6 viremia in bone marrow transplant recipients: Clinical features and risk factors', Journal of Infectious Diseases, vol. 185, no. 7, pp. 847-853. https://doi.org/10.1086/339411

Human herpesvirus 6 viremia in bone marrow transplant recipients : Clinical features and risk factors. / Yoshikawa, Tetsushi; Asano, Yoshizo; Ihira, Masaru; Suzuki, Kyoko; Ohashi, Masahiro; Suga, Sadao; Kudo, Kazuko; Horibe, Keizo; Kojima, Seiji; Kato, Koji; Matsuyama, Takaharu; Nishiyama, Yukihiro.

In: Journal of Infectious Diseases, Vol. 185, No. 7, 01.04.2002, p. 847-853.

Research output: Contribution to journalArticle

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T1 - Human herpesvirus 6 viremia in bone marrow transplant recipients

T2 - Clinical features and risk factors

AU - Yoshikawa, Tetsushi

AU - Asano, Yoshizo

AU - Ihira, Masaru

AU - Suzuki, Kyoko

AU - Ohashi, Masahiro

AU - Suga, Sadao

AU - Kudo, Kazuko

AU - Horibe, Keizo

AU - Kojima, Seiji

AU - Kato, Koji

AU - Matsuyama, Takaharu

AU - Nishiyama, Yukihiro

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N2 - Human herpesvirus 6 (HHV-6) infection was studied in 82 bone marrow transplant (BMT) recipients (72 allogeneic, 10 autologous). All recipients and 30 donors were seropositive for HHV-6 antibody at the time of bone marrow transplantation. Thirty-one recipients (37.8%) had HHV-6 viremia 2-4 weeks after transplantation. The incidence of HHV-6 viremia was significantly higher among allogeneic BMT recipients than in autologous BMT recipients (P = .011). Therefore, the following analyses of allogeneic BMT recipients were carried out (n = 72). Geometric mean antibody titers (log10) were significantly higher in recipients without viremia than in those with viremia (1.84 ± 0.39 vs. 1.61 ± 0.42; P = .022). Logistic regression analysis demonstrated that leukemia or lymphoma is an independent risk factor (P = .031) for HHV-6 viremia. Rash occurring within 1 month after transplantation was observed in 17 (54.8%) of 31 recipients with HHV-6 viremia but in only 8 (19.5%) of 41 recipients without HHV-6 viremia (P = .001).

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