Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation

Tetsushi Yoshikawa, Jun Yoshida, Motohiro Hamaguchi, Toshinobu Kubota, Shiho Akimoto, Masaru Ihira, Yukihiro Nishiyama, Yoshizo Asano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A 9-year-old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition to vomiting, the patient had a fever (from day 26) and severe headache (from day 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although the patient's symptoms were resolved with further supportive care, abrupt onset of bilateral decreased vision occurred at day 54. He was diagnosed with bilateral optic neuritis, due to the presence of disc edema and redness. Concomitant with the occurrence of aseptic meningitis, the human herpesvirus 7 (HHV-7) antibody titer increased significantly in this patient. Although neither HHV-6 nor cytomegalovirus (CMV) DNA was detected in CSF collected at day 41, HHV-7 DNA was detected in the sample. Viral DNA was not detected in CSF collected at day 93.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalJournal of Medical Virology
Volume70
Issue number3
DOIs
Publication statusPublished - 01-07-2003

Fingerprint

Human Herpesvirus 7
Optic Neuritis
Stem Cell Transplantation
Meningitis
Cerebrospinal Fluid
Human Herpesvirus 6
Aseptic Meningitis
DNA
Leukocytosis
Viral DNA
Cytomegalovirus
Vomiting
Headache
Edema
Fever
Transplantation
Antibodies

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Yoshikawa, Tetsushi ; Yoshida, Jun ; Hamaguchi, Motohiro ; Kubota, Toshinobu ; Akimoto, Shiho ; Ihira, Masaru ; Nishiyama, Yukihiro ; Asano, Yoshizo. / Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation. In: Journal of Medical Virology. 2003 ; Vol. 70, No. 3. pp. 440-443.
@article{16e3f8d8af4a47d786295b85cc669ed8,
title = "Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation",
abstract = "A 9-year-old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition to vomiting, the patient had a fever (from day 26) and severe headache (from day 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although the patient's symptoms were resolved with further supportive care, abrupt onset of bilateral decreased vision occurred at day 54. He was diagnosed with bilateral optic neuritis, due to the presence of disc edema and redness. Concomitant with the occurrence of aseptic meningitis, the human herpesvirus 7 (HHV-7) antibody titer increased significantly in this patient. Although neither HHV-6 nor cytomegalovirus (CMV) DNA was detected in CSF collected at day 41, HHV-7 DNA was detected in the sample. Viral DNA was not detected in CSF collected at day 93.",
author = "Tetsushi Yoshikawa and Jun Yoshida and Motohiro Hamaguchi and Toshinobu Kubota and Shiho Akimoto and Masaru Ihira and Yukihiro Nishiyama and Yoshizo Asano",
year = "2003",
month = "7",
day = "1",
doi = "10.1002/jmv.10414",
language = "English",
volume = "70",
pages = "440--443",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "3",

}

Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation. / Yoshikawa, Tetsushi; Yoshida, Jun; Hamaguchi, Motohiro; Kubota, Toshinobu; Akimoto, Shiho; Ihira, Masaru; Nishiyama, Yukihiro; Asano, Yoshizo.

In: Journal of Medical Virology, Vol. 70, No. 3, 01.07.2003, p. 440-443.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation

AU - Yoshikawa, Tetsushi

AU - Yoshida, Jun

AU - Hamaguchi, Motohiro

AU - Kubota, Toshinobu

AU - Akimoto, Shiho

AU - Ihira, Masaru

AU - Nishiyama, Yukihiro

AU - Asano, Yoshizo

PY - 2003/7/1

Y1 - 2003/7/1

N2 - A 9-year-old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition to vomiting, the patient had a fever (from day 26) and severe headache (from day 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although the patient's symptoms were resolved with further supportive care, abrupt onset of bilateral decreased vision occurred at day 54. He was diagnosed with bilateral optic neuritis, due to the presence of disc edema and redness. Concomitant with the occurrence of aseptic meningitis, the human herpesvirus 7 (HHV-7) antibody titer increased significantly in this patient. Although neither HHV-6 nor cytomegalovirus (CMV) DNA was detected in CSF collected at day 41, HHV-7 DNA was detected in the sample. Viral DNA was not detected in CSF collected at day 93.

AB - A 9-year-old boy who received allogeneic stem cell transplantation began to vomit from day 10 after transplantation. In addition to vomiting, the patient had a fever (from day 26) and severe headache (from day 34). His cerebrospinal fluid (CSF) (day 41) demonstrated pleocytosis with an absence of leukemic cells. Although the patient's symptoms were resolved with further supportive care, abrupt onset of bilateral decreased vision occurred at day 54. He was diagnosed with bilateral optic neuritis, due to the presence of disc edema and redness. Concomitant with the occurrence of aseptic meningitis, the human herpesvirus 7 (HHV-7) antibody titer increased significantly in this patient. Although neither HHV-6 nor cytomegalovirus (CMV) DNA was detected in CSF collected at day 41, HHV-7 DNA was detected in the sample. Viral DNA was not detected in CSF collected at day 93.

UR - http://www.scopus.com/inward/record.url?scp=0038700549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038700549&partnerID=8YFLogxK

U2 - 10.1002/jmv.10414

DO - 10.1002/jmv.10414

M3 - Article

C2 - 12767008

AN - SCOPUS:0038700549

VL - 70

SP - 440

EP - 443

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 3

ER -