Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-

Yutaka Tokumaru; Masato Fujii; Katsunari Yane; Takanori Hama; Kiyoto Shiga; Hiroyuki Mineta; Tomokazu Yoshizaki; Kenji Okami; Ichiro Ota; Shigeru Hirano; Muneyuki Masuda; Masashi Sugasawa; Torahiko Nakashima; Toyoyuki Hanazawa; Noriyuki Sakihama; Yuichiro Kuratomi; Ken ichi Nibu; Hisayuki Kato; Yorihisa Imanishi; Taro Sugimoto; Shinsuke Suzuki; Yuichiro Sato

doi:10.5981/jjhnc.37.398

Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-

Yutaka Tokumaru, Masato Fujii, Katsunari Yane, Takanori Hama, Kiyoto Shiga, Hiroyuki Mineta, Tomokazu Yoshizaki, Kenji Okami, Ichiro Ota, Shigeru Hirano, Muneyuki Masuda, Masashi Sugasawa, Torahiko Nakashima, Toyoyuki Hanazawa, Noriyuki Sakihama, Yuichiro Kuratomi, Ken ichi Nibu, Hisayuki Kato, Yorihisa Imanishi, Taro SugimotoShinsuke Suzuki, Yuichiro Sato

Department of Otolaryngology ・ Head and Neck Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer performed a multicenter prospective study to clarify the prevalence and genotype distribution of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) in Japan. Tumor tissues from 148 patients with newly diagnosed oropharyngeal SCC were tested for the presence of HPV genome by using polymerase chain reaction (PCR) and Hybrid Capture 2 (HC2). Non-cancerous palatine tonsils from 53 patients with tonsillectomy due to habitual tonsillitis or tonsillar hypertrophy were also examined as controls. High-risk HPV was detected in 76 (51.4%)of 148 tumor cases and none of 53 controls by PCR. HPV type distribution revealed HPV16 in 69 cases (90.8%), HPV18 and 58 in 2 cases each (2.6%), and HPV31, 35, and 56 in 1 case (1.3%) each. Compared with HPV-negative oropharyngeal cancers, HPV-positive oropharyngeal cancers were less likely to occur among smokers and drinkers. In addition, detection of HPV using HC2 in oral brushing revealed that sensitivity and specificity were 90.7% and 97.1% respectively. This HC2 detection for HPV is considered to be effective and less invasive for patients with oropharyngeal SCC.

Original language	English
Pages (from-to)	398-404
Number of pages	7
Journal	Japanese Journal of Head and Neck Cancer
Volume	37
Issue number	3
DOIs	https://doi.org/10.5981/jjhnc.37.398
Publication status	Published - 2011

All Science Journal Classification (ASJC) codes

Otorhinolaryngology
Oncology

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10.5981/jjhnc.37.398

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Tokumaru, Y., Fujii, M., Yane, K., Hama, T., Shiga, K., Mineta, H., Yoshizaki, T., Okami, K., Ota, I., Hirano, S., Masuda, M., Sugasawa, M., Nakashima, T., Hanazawa, T., Sakihama, N., Kuratomi, Y., Nibu, K. I., Kato, H., Imanishi, Y., ... Sato, Y. (2011). Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-. Japanese Journal of Head and Neck Cancer, 37(3), 398-404. https://doi.org/10.5981/jjhnc.37.398

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title = "Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-",

abstract = "The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer performed a multicenter prospective study to clarify the prevalence and genotype distribution of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) in Japan. Tumor tissues from 148 patients with newly diagnosed oropharyngeal SCC were tested for the presence of HPV genome by using polymerase chain reaction (PCR) and Hybrid Capture 2 (HC2). Non-cancerous palatine tonsils from 53 patients with tonsillectomy due to habitual tonsillitis or tonsillar hypertrophy were also examined as controls. High-risk HPV was detected in 76 (51.4%)of 148 tumor cases and none of 53 controls by PCR. HPV type distribution revealed HPV16 in 69 cases (90.8%), HPV18 and 58 in 2 cases each (2.6%), and HPV31, 35, and 56 in 1 case (1.3%) each. Compared with HPV-negative oropharyngeal cancers, HPV-positive oropharyngeal cancers were less likely to occur among smokers and drinkers. In addition, detection of HPV using HC2 in oral brushing revealed that sensitivity and specificity were 90.7% and 97.1% respectively. This HC2 detection for HPV is considered to be effective and less invasive for patients with oropharyngeal SCC.",

keywords = "Human papillomavirus, Hybrid capture 2, Multicenter study, Oropharyngeal cancer, PCR",

author = "Yutaka Tokumaru and Masato Fujii and Katsunari Yane and Takanori Hama and Kiyoto Shiga and Hiroyuki Mineta and Tomokazu Yoshizaki and Kenji Okami and Ichiro Ota and Shigeru Hirano and Muneyuki Masuda and Masashi Sugasawa and Torahiko Nakashima and Toyoyuki Hanazawa and Noriyuki Sakihama and Yuichiro Kuratomi and Nibu, {Ken ichi} and Hisayuki Kato and Yorihisa Imanishi and Taro Sugimoto and Shinsuke Suzuki and Yuichiro Sato",

year = "2011",

doi = "10.5981/jjhnc.37.398",

language = "English",

volume = "37",

pages = "398--404",

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Tokumaru, Y, Fujii, M, Yane, K, Hama, T, Shiga, K, Mineta, H, Yoshizaki, T, Okami, K, Ota, I, Hirano, S, Masuda, M, Sugasawa, M, Nakashima, T, Hanazawa, T, Sakihama, N, Kuratomi, Y, Nibu, KI, Kato, H, Imanishi, Y, Sugimoto, T, Suzuki, S & Sato, Y 2011, 'Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-', Japanese Journal of Head and Neck Cancer, vol. 37, no. 3, pp. 398-404. https://doi.org/10.5981/jjhnc.37.398

TY - JOUR

T1 - Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-

AU - Tokumaru, Yutaka

AU - Fujii, Masato

AU - Yane, Katsunari

AU - Hama, Takanori

AU - Shiga, Kiyoto

AU - Mineta, Hiroyuki

AU - Yoshizaki, Tomokazu

AU - Okami, Kenji

AU - Ota, Ichiro

AU - Hirano, Shigeru

AU - Masuda, Muneyuki

AU - Sugasawa, Masashi

AU - Nakashima, Torahiko

AU - Hanazawa, Toyoyuki

AU - Sakihama, Noriyuki

AU - Kuratomi, Yuichiro

AU - Nibu, Ken ichi

AU - Kato, Hisayuki

AU - Imanishi, Yorihisa

AU - Sugimoto, Taro

AU - Suzuki, Shinsuke

AU - Sato, Yuichiro

PY - 2011

Y1 - 2011

N2 - The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer performed a multicenter prospective study to clarify the prevalence and genotype distribution of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) in Japan. Tumor tissues from 148 patients with newly diagnosed oropharyngeal SCC were tested for the presence of HPV genome by using polymerase chain reaction (PCR) and Hybrid Capture 2 (HC2). Non-cancerous palatine tonsils from 53 patients with tonsillectomy due to habitual tonsillitis or tonsillar hypertrophy were also examined as controls. High-risk HPV was detected in 76 (51.4%)of 148 tumor cases and none of 53 controls by PCR. HPV type distribution revealed HPV16 in 69 cases (90.8%), HPV18 and 58 in 2 cases each (2.6%), and HPV31, 35, and 56 in 1 case (1.3%) each. Compared with HPV-negative oropharyngeal cancers, HPV-positive oropharyngeal cancers were less likely to occur among smokers and drinkers. In addition, detection of HPV using HC2 in oral brushing revealed that sensitivity and specificity were 90.7% and 97.1% respectively. This HC2 detection for HPV is considered to be effective and less invasive for patients with oropharyngeal SCC.

AB - The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer performed a multicenter prospective study to clarify the prevalence and genotype distribution of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (SCC) in Japan. Tumor tissues from 148 patients with newly diagnosed oropharyngeal SCC were tested for the presence of HPV genome by using polymerase chain reaction (PCR) and Hybrid Capture 2 (HC2). Non-cancerous palatine tonsils from 53 patients with tonsillectomy due to habitual tonsillitis or tonsillar hypertrophy were also examined as controls. High-risk HPV was detected in 76 (51.4%)of 148 tumor cases and none of 53 controls by PCR. HPV type distribution revealed HPV16 in 69 cases (90.8%), HPV18 and 58 in 2 cases each (2.6%), and HPV31, 35, and 56 in 1 case (1.3%) each. Compared with HPV-negative oropharyngeal cancers, HPV-positive oropharyngeal cancers were less likely to occur among smokers and drinkers. In addition, detection of HPV using HC2 in oral brushing revealed that sensitivity and specificity were 90.7% and 97.1% respectively. This HC2 detection for HPV is considered to be effective and less invasive for patients with oropharyngeal SCC.

KW - Human papillomavirus

KW - Hybrid capture 2

KW - Multicenter study

KW - Oropharyngeal cancer

KW - PCR

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SN - 1349-5747

VL - 37

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JO - Japanese Journal of Head and Neck Cancer

JF - Japanese Journal of Head and Neck Cancer

IS - 3

ER -

Human papillomavirus in oropharyngeal squamous cell carcinoma-A multicenter prospective study in Japan-

Abstract

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