Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

Takashi Namba; Judit Dóczi; Anneline Pinson; Lei Xing; Nereo Kalebic; Michaela Wilsch-Bräuninger; Katherine R. Long; Samir Vaid; Janelle Lauer; Aliona Bogdanova; Barbara Borgonovo; Anna Shevchenko; Patrick Keller; David Drechsel; Teymuras Kurzchalia; Pauline Wimberger; Christos Chinopoulos; Wieland B. Huttner

doi:10.1016/j.neuron.2019.11.027

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

Takashi Namba
, Judit Dóczi
, Anneline Pinson
, Lei Xing
, Nereo Kalebic
, Michaela Wilsch-Bräuninger
, Katherine R. Long
, Samir Vaid
, Janelle Lauer
, Aliona Bogdanova
, Barbara Borgonovo
, Anna Shevchenko
, Patrick Keller
, David Drechsel
, Teymuras Kurzchalia
, Pauline Wimberger
, Christos Chinopoulos
, Wieland B. Huttner

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.

Original language	English
Pages (from-to)	867-881.e9
Journal	Neuron
Volume	105
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2019.11.027
Publication status	Published - 04-03-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2019.11.027

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Namba, T., Dóczi, J., Pinson, A., Xing, L., Kalebic, N., Wilsch-Bräuninger, M., Long, K. R., Vaid, S., Lauer, J., Bogdanova, A., Borgonovo, B., Shevchenko, A., Keller, P., Drechsel, D., Kurzchalia, T., Wimberger, P., Chinopoulos, C., & Huttner, W. B. (2020). Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis. Neuron, 105(5), 867-881.e9. https://doi.org/10.1016/j.neuron.2019.11.027

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title = "Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis",

abstract = "Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.",

keywords = "evolution, metabolism, neocortex, neural progenitor cells",

author = "Takashi Namba and Judit D{\'o}czi and Anneline Pinson and Lei Xing and Nereo Kalebic and Michaela Wilsch-Br{\"a}uninger and Long, \{Katherine R.\} and Samir Vaid and Janelle Lauer and Aliona Bogdanova and Barbara Borgonovo and Anna Shevchenko and Patrick Keller and David Drechsel and Teymuras Kurzchalia and Pauline Wimberger and Christos Chinopoulos and Huttner, \{Wieland B.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = mar,

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doi = "10.1016/j.neuron.2019.11.027",

language = "English",

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Namba, T, Dóczi, J, Pinson, A, Xing, L, Kalebic, N, Wilsch-Bräuninger, M, Long, KR, Vaid, S, Lauer, J, Bogdanova, A, Borgonovo, B, Shevchenko, A, Keller, P, Drechsel, D, Kurzchalia, T, Wimberger, P, Chinopoulos, C & Huttner, WB 2020, 'Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis', Neuron, vol. 105, no. 5, pp. 867-881.e9. https://doi.org/10.1016/j.neuron.2019.11.027

TY - JOUR

T1 - Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

AU - Namba, Takashi

AU - Dóczi, Judit

AU - Pinson, Anneline

AU - Xing, Lei

AU - Kalebic, Nereo

AU - Wilsch-Bräuninger, Michaela

AU - Long, Katherine R.

AU - Vaid, Samir

AU - Lauer, Janelle

AU - Bogdanova, Aliona

AU - Borgonovo, Barbara

AU - Shevchenko, Anna

AU - Keller, Patrick

AU - Drechsel, David

AU - Kurzchalia, Teymuras

AU - Wimberger, Pauline

AU - Chinopoulos, Christos

AU - Huttner, Wieland B.

PY - 2020/3/4

Y1 - 2020/3/4

N2 - Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.

AB - Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.

KW - evolution

KW - metabolism

KW - neocortex

KW - neural progenitor cells

UR - https://www.scopus.com/pages/publications/85080065568

UR - https://www.scopus.com/pages/publications/85080065568#tab=citedBy

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DO - 10.1016/j.neuron.2019.11.027

M3 - Article

C2 - 31883789

AN - SCOPUS:85080065568

SN - 0896-6273

VL - 105

SP - 867-881.e9

JO - Neuron

JF - Neuron

IS - 5

ER -

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

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