Human vascular endothelial cell adhesion receptors for plasmoclium falciparum-infected erythrocytes: Roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1

Christian F. Ockenhouse, Tatsuya Tegoshi, Yoshimasa Maeno, Christopher Benjamin, May Ho, Khin Ei Kan, Ye Thway, Kyan Win, Masamichi Aikawa, Roy R. Lobb

Research output: Contribution to journalArticle

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Abstract

The clinical complications associated with severe and cerebral malaria occur as a result of the intravascular mechanical obstruction of erythrocytes infected with the asexual stages of the parasite, Plasmodiumfakiparum. We now report that a primary P.fakiparum-infected erythrocyte (parasitized red blood cell [PRBC]) isolate from a patient with severe complicated malaria binds to cytokineinduced human vascular endothelial cells, and that this adhesion is in part mediated by endothelial leukocyte adhesion molecule 1 (ELAM-1) and vascular cell adhesion molecule 1 (VCAM-1). PRBC binding to tumor necrosis factor α (TNF-α-activated human vascular endothelial cells is partially inhibited by antibodies to ELAM-1 and ICAM-1 and the inhibitory effects of these antibodies is additive. PRBCs selected in vitro by sequential panning on purified adhesion molecules bind concurrently to recombinant soluble ELAM-1 and VCAM-1, and to two previously identified endothelial cell receptors for PRBCs, ICAM-1, and CD36. Post-mortem brain tissue from patients who died from cerebral malaria expressed multiple cell adhesion molecules including ELAM-1 and VCAM-1 on cerebral microvascular endothelium not expressed in brains of individuals who died from other causes. These results ascribe novel pathological functions for both ELAM-1 and VCAM-1 and may help delineate alternative adhesion pathways PRBCs use to modify malaria pathology.

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalJournal of Experimental Medicine
Volume176
Issue number4
DOIs
Publication statusPublished - 01-10-1992

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E-Selectin
Vascular Cell Adhesion Molecule-1
Cell Adhesion
Endothelial Cells
Erythrocytes
Cerebral Malaria
Intercellular Adhesion Molecule-1
Malaria
Antibodies
Brain
Cell Adhesion Molecules
Endothelium
Parasites
Tumor Necrosis Factor-alpha
adhesion receptor
Pathology

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Ockenhouse, Christian F. ; Tegoshi, Tatsuya ; Maeno, Yoshimasa ; Benjamin, Christopher ; Ho, May ; Kan, Khin Ei ; Thway, Ye ; Win, Kyan ; Aikawa, Masamichi ; Lobb, Roy R. / Human vascular endothelial cell adhesion receptors for plasmoclium falciparum-infected erythrocytes : Roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. In: Journal of Experimental Medicine. 1992 ; Vol. 176, No. 4. pp. 1183-1189.
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Human vascular endothelial cell adhesion receptors for plasmoclium falciparum-infected erythrocytes : Roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. / Ockenhouse, Christian F.; Tegoshi, Tatsuya; Maeno, Yoshimasa; Benjamin, Christopher; Ho, May; Kan, Khin Ei; Thway, Ye; Win, Kyan; Aikawa, Masamichi; Lobb, Roy R.

In: Journal of Experimental Medicine, Vol. 176, No. 4, 01.10.1992, p. 1183-1189.

Research output: Contribution to journalArticle

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T2 - Roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1

AU - Ockenhouse, Christian F.

AU - Tegoshi, Tatsuya

AU - Maeno, Yoshimasa

AU - Benjamin, Christopher

AU - Ho, May

AU - Kan, Khin Ei

AU - Thway, Ye

AU - Win, Kyan

AU - Aikawa, Masamichi

AU - Lobb, Roy R.

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