Hybrid liposomes affect cellular lipid constituents and caveolae structures

Ke Cao, Kouji Tanaka, Yuji Komizu, Keiko Tamiya-Koizumi, Takashi Murate, Ryuichi Ueoka, Mamoru Kyogashima, Jiro Usukura, Takashi Takahashi, Motoshi Suzuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

Original languageEnglish
Pages (from-to)1731-1733
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number4
DOIs
Publication statusPublished - 15-02-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Cao, K., Tanaka, K., Komizu, Y., Tamiya-Koizumi, K., Murate, T., Ueoka, R., Kyogashima, M., Usukura, J., Takahashi, T., & Suzuki, M. (2012). Hybrid liposomes affect cellular lipid constituents and caveolae structures. Bioorganic and Medicinal Chemistry Letters, 22(4), 1731-1733. https://doi.org/10.1016/j.bmcl.2011.12.093