Hybrid liposomes affect cellular lipid constituents and caveolae structures

Ke Cao; Kouji Tanaka; Yuji Komizu; Keiko Tamiya-Koizumi; Takashi Murate; Ryuichi Ueoka; Mamoru Kyogashima; Jiro Usukura; Takashi Takahashi; Motoshi Suzuki

doi:10.1016/j.bmcl.2011.12.093

Hybrid liposomes affect cellular lipid constituents and caveolae structures

Ke Cao
, Kouji Tanaka
, Yuji Komizu
, Keiko Tamiya-Koizumi
, Takashi Murate
, Ryuichi Ueoka
, Mamoru Kyogashima
, Jiro Usukura
, Takashi Takahashi
, Motoshi Suzuki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

Original language	English
Pages (from-to)	1731-1733
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2011.12.093
Publication status	Published - 15-02-2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.12.093

Cite this

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title = "Hybrid liposomes affect cellular lipid constituents and caveolae structures",

abstract = "We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.",

author = "Ke Cao and Kouji Tanaka and Yuji Komizu and Keiko Tamiya-Koizumi and Takashi Murate and Ryuichi Ueoka and Mamoru Kyogashima and Jiro Usukura and Takashi Takahashi and Motoshi Suzuki",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. We thank Dr. Mitsuhiro Nakamura of Gifu Pharmaceutical University and Dr. Yoshiko Banno for Gifu University Graduate School of Medicine for the critical discussion. ",

year = "2012",

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doi = "10.1016/j.bmcl.2011.12.093",

language = "English",

volume = "22",

pages = "1731--1733",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Hybrid liposomes affect cellular lipid constituents and caveolae structures

AU - Cao, Ke

AU - Tanaka, Kouji

AU - Komizu, Yuji

AU - Tamiya-Koizumi, Keiko

AU - Murate, Takashi

AU - Ueoka, Ryuichi

AU - Kyogashima, Mamoru

AU - Usukura, Jiro

AU - Takahashi, Takashi

AU - Suzuki, Motoshi

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. We thank Dr. Mitsuhiro Nakamura of Gifu Pharmaceutical University and Dr. Yoshiko Banno for Gifu University Graduate School of Medicine for the critical discussion.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

AB - We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

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UR - https://www.scopus.com/pages/publications/84862788946#tab=citedBy

U2 - 10.1016/j.bmcl.2011.12.093

DO - 10.1016/j.bmcl.2011.12.093

M3 - Article

C2 - 22248855

AN - SCOPUS:84862788946

SN - 0960-894X

VL - 22

SP - 1731

EP - 1733

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Hybrid liposomes affect cellular lipid constituents and caveolae structures

Abstract

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All Science Journal Classification (ASJC) codes

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