Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease

Ikuya Tsuge, Yasuto Kondo, Yoichi Nakajima, Noriko Nakagawa, Kohsuke Imai, Shigeaki Nonoyama, Koichi Oshima, Osamu Ohara, Michiyo Hatanaka, Etsuko Kitano, Hajime Kitamura, Atsuo Urisu

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Abstract

Many immunedeficiency syndromes are associated with autoimmune disorders. We here report on a girl with a systemic lupus erythematosus-like disease who suffered from both hyperimmunoglobulin M syndrome (HIGMS) and C1q deficiency. Despite severe central nervous system-lupus like disease, probably due to C1q deficiency, kidney function was relatively spared. IgM autoantibody might play a protective role against lupus-glomerulonephritis.

Original languageEnglish
Pages (from-to)558-560
Number of pages3
JournalClinical and Experimental Rheumatology
Volume28
Issue number4
Publication statusPublished - 01-12-2010

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All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Tsuge, I., Kondo, Y., Nakajima, Y., Nakagawa, N., Imai, K., Nonoyama, S., Oshima, K., Ohara, O., Hatanaka, M., Kitano, E., Kitamura, H., & Urisu, A. (2010). Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease. Clinical and Experimental Rheumatology, 28(4), 558-560.