Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease

Ikuya Tsuge, Yasuto Kondo, Yoichi Nakajima, Noriko Nakagawa, Kohsuke Imai, Shigeaki Nonoyama, Koichi Oshima, Osamu Ohara, Michiyo Hatanaka, Etsuko Kitano, Hajime Kitamura, Atsuo Urisu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Many immunedeficiency syndromes are associated with autoimmune disorders. We here report on a girl with a systemic lupus erythematosus-like disease who suffered from both hyperimmunoglobulin M syndrome (HIGMS) and C1q deficiency. Despite severe central nervous system-lupus like disease, probably due to C1q deficiency, kidney function was relatively spared. IgM autoantibody might play a protective role against lupus-glomerulonephritis.

Original languageEnglish
Pages (from-to)558-560
Number of pages3
JournalClinical and Experimental Rheumatology
Volume28
Issue number4
Publication statusPublished - 01-12-2010

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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