Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease

Ikuya Tsuge, Yasuto Kondo, Yoichi Nakajima, Noriko Nakagawa, Kohsuke Imai, Shigeaki Nonoyama, Koichi Oshima, Osamu Ohara, Michiyo Hatanaka, Etsuko Kitano, Hajime Kitamura, Atsuo Urisu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Many immunedeficiency syndromes are associated with autoimmune disorders. We here report on a girl with a systemic lupus erythematosus-like disease who suffered from both hyperimmunoglobulin M syndrome (HIGMS) and C1q deficiency. Despite severe central nervous system-lupus like disease, probably due to C1q deficiency, kidney function was relatively spared. IgM autoantibody might play a protective role against lupus-glomerulonephritis.

Original languageEnglish
Pages (from-to)558-560
Number of pages3
JournalClinical and Experimental Rheumatology
Volume28
Issue number4
Publication statusPublished - 01-12-2010

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Hyper-IgM Immunodeficiency Syndrome
Systemic Lupus Erythematosus
Central Nervous System Lupus Vasculitis
Lupus Nephritis
Autoantibodies
Immunoglobulin M
Kidney

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Tsuge, Ikuya ; Kondo, Yasuto ; Nakajima, Yoichi ; Nakagawa, Noriko ; Imai, Kohsuke ; Nonoyama, Shigeaki ; Oshima, Koichi ; Ohara, Osamu ; Hatanaka, Michiyo ; Kitano, Etsuko ; Kitamura, Hajime ; Urisu, Atsuo. / Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease. In: Clinical and Experimental Rheumatology. 2010 ; Vol. 28, No. 4. pp. 558-560.
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author = "Ikuya Tsuge and Yasuto Kondo and Yoichi Nakajima and Noriko Nakagawa and Kohsuke Imai and Shigeaki Nonoyama and Koichi Oshima and Osamu Ohara and Michiyo Hatanaka and Etsuko Kitano and Hajime Kitamura and Atsuo Urisu",
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Tsuge, I, Kondo, Y, Nakajima, Y, Nakagawa, N, Imai, K, Nonoyama, S, Oshima, K, Ohara, O, Hatanaka, M, Kitano, E, Kitamura, H & Urisu, A 2010, 'Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease', Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. 558-560.

Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease. / Tsuge, Ikuya; Kondo, Yasuto; Nakajima, Yoichi; Nakagawa, Noriko; Imai, Kohsuke; Nonoyama, Shigeaki; Oshima, Koichi; Ohara, Osamu; Hatanaka, Michiyo; Kitano, Etsuko; Kitamura, Hajime; Urisu, Atsuo.

In: Clinical and Experimental Rheumatology, Vol. 28, No. 4, 01.12.2010, p. 558-560.

Research output: Contribution to journalArticle

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AU - Tsuge, Ikuya

AU - Kondo, Yasuto

AU - Nakajima, Yoichi

AU - Nakagawa, Noriko

AU - Imai, Kohsuke

AU - Nonoyama, Shigeaki

AU - Oshima, Koichi

AU - Ohara, Osamu

AU - Hatanaka, Michiyo

AU - Kitano, Etsuko

AU - Kitamura, Hajime

AU - Urisu, Atsuo

PY - 2010/12/1

Y1 - 2010/12/1

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AB - Many immunedeficiency syndromes are associated with autoimmune disorders. We here report on a girl with a systemic lupus erythematosus-like disease who suffered from both hyperimmunoglobulin M syndrome (HIGMS) and C1q deficiency. Despite severe central nervous system-lupus like disease, probably due to C1q deficiency, kidney function was relatively spared. IgM autoantibody might play a protective role against lupus-glomerulonephritis.

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