TY - JOUR
T1 - Hyperferritinemia after adult allogeneic hematopoietic cell transplantation
T2 - Quantification of iron burden by determining non-transferrin-bound iron
AU - Goto, Tatsunori
AU - Ikuta, Katsuya
AU - Inamoto, Yoshihiro
AU - Kamoshita, Sonoko
AU - Yokohata, Emi
AU - Koyama, Daisuke
AU - Onodera, Koichi
AU - Seto, Aika
AU - Watanabe, Keisuke
AU - Imahashi, Nobuhiko
AU - Tsukamoto, Shokichi
AU - Ozawa, Yukiyasu
AU - Sasaki, Katsunori
AU - Ito, Masafumi
AU - Kohgo, Yutaka
AU - Miyamura, Koichi
PY - 2013/1
Y1 - 2013/1
N2 - Iron overload is a common complication in allogeneic hematopoietic cell transplantation (HCT). We studied the prevalence of iron overload using serum ferritin from 122 allogeneic HCT survivors who had survived a median of 1259 (range 134-4261) days. We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay. Fifty-two patients (43 %) showed hyperferritinemia (HF) (serum ferritin >1000 ng/mL), and there was a moderate correlation between serum ferritin and the number of transfused red blood cell units (ρ = 0.71). In multivariate analyses, HF was a significant risk factor for liver dysfunction (P = 0.0001) and diabetes (P = 0.02), and was related to a lesser extent with performance status (P = 0.08). There was a significant correlation between serum ferritin and NTBI (ρ = 0.59); however, the association of NTBI with these outcomes was weaker than that of serum ferritin. In conclusion, serum ferritin is a good surrogate marker of iron overload after allogeneic HCT, and reflects organ damage more accurately than NTBI.
AB - Iron overload is a common complication in allogeneic hematopoietic cell transplantation (HCT). We studied the prevalence of iron overload using serum ferritin from 122 allogeneic HCT survivors who had survived a median of 1259 (range 134-4261) days. We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay. Fifty-two patients (43 %) showed hyperferritinemia (HF) (serum ferritin >1000 ng/mL), and there was a moderate correlation between serum ferritin and the number of transfused red blood cell units (ρ = 0.71). In multivariate analyses, HF was a significant risk factor for liver dysfunction (P = 0.0001) and diabetes (P = 0.02), and was related to a lesser extent with performance status (P = 0.08). There was a significant correlation between serum ferritin and NTBI (ρ = 0.59); however, the association of NTBI with these outcomes was weaker than that of serum ferritin. In conclusion, serum ferritin is a good surrogate marker of iron overload after allogeneic HCT, and reflects organ damage more accurately than NTBI.
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U2 - 10.1007/s12185-012-1252-1
DO - 10.1007/s12185-012-1252-1
M3 - Article
C2 - 23264147
AN - SCOPUS:84872932126
SN - 0925-5710
VL - 97
SP - 125
EP - 134
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 1
ER -