Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa; M. Matsumoto; M. Tagaya; K. Kuwabara; R. Hata; N. Handa; R. Fukunaga; K. Kimura; T. Kamada

doi:10.1038/jcbfm.1991.86

Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa, M. Matsumoto, M. Tagaya, K. Kuwabara, R. Hata, N. Handa, R. Fukunaga, K. Kimura, T. Kamada

Anatomy Ⅰ

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

Original language	English
Pages (from-to)	449-452
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	11
Issue number	3
DOIs	https://doi.org/10.1038/jcbfm.1991.86
Publication status	Published - 1991

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

Access to Document

10.1038/jcbfm.1991.86

Fingerprint Dive into the research topics of 'Hyperthermia-induced neuronal protection against ischemic injury in gerbils'. Together they form a unique fingerprint.

Cite this

@article{9ed38fcaf635447483ff775e09b304c3,

title = "Hyperthermia-induced neuronal protection against ischemic injury in gerbils",

abstract = "We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.",

author = "K. Kitagawa and M. Matsumoto and M. Tagaya and K. Kuwabara and R. Hata and N. Handa and R. Fukunaga and K. Kimura and T. Kamada",

year = "1991",

doi = "10.1038/jcbfm.1991.86",

language = "English",

volume = "11",

pages = "449--452",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Hyperthermia-induced neuronal protection against ischemic injury in gerbils

AU - Kitagawa, K.

AU - Matsumoto, M.

AU - Tagaya, M.

AU - Kuwabara, K.

AU - Hata, R.

AU - Handa, N.

AU - Fukunaga, R.

AU - Kimura, K.

AU - Kamada, T.

PY - 1991

Y1 - 1991

N2 - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

AB - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

UR - http://www.scopus.com/inward/record.url?scp=0025845010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025845010&partnerID=8YFLogxK

U2 - 10.1038/jcbfm.1991.86

DO - 10.1038/jcbfm.1991.86

M3 - Article

C2 - 2016352

AN - SCOPUS:0025845010

VL - 11

SP - 449

EP - 452

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 3

ER -