Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa, M. Matsumoto, M. Tagaya, K. Kuwabara, R. Hata, N. Handa, R. Fukunaga, K. Kimura, T. Kamada

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130 Citations (Scopus)

Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume11
Issue number3
DOIs
Publication statusPublished - 1991

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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