Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa; M. Matsumoto; M. Tagaya; K. Kuwabara; Ryuji Hata; N. Handa; R. Fukunaga; K. Kimura; T. Kamada

doi:10.1038/jcbfm.1991.86

Hyperthermia-induced neuronal protection against ischemic injury in gerbils

K. Kitagawa, M. Matsumoto, M. Tagaya, K. Kuwabara, Ryuji Hata, N. Handa, R. Fukunaga, K. Kimura, T. Kamada

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Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.

Original language	English
Pages (from-to)	449-452
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	11
Issue number	3
DOIs	https://doi.org/10.1038/jcbfm.1991.86
Publication status	Published - 01-01-1991

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All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

Cite this

Kitagawa, K., Matsumoto, M., Tagaya, M., Kuwabara, K., Hata, R., Handa, N., Fukunaga, R., Kimura, K., & Kamada, T. (1991). Hyperthermia-induced neuronal protection against ischemic injury in gerbils. Journal of Cerebral Blood Flow and Metabolism, 11(3), 449-452. https://doi.org/10.1038/jcbfm.1991.86

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10.1038/jcbfm.1991.86