Abstract
We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.
| Original language | English |
|---|---|
| Pages (from-to) | 449-452 |
| Number of pages | 4 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1991 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
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Hyperthermia-induced neuronal protection against ischemic injury in gerbils. / Kitagawa, K.; Matsumoto, M.; Tagaya, M.; Kuwabara, K.; Hata, Ryuji; Handa, N.; Fukunaga, R.; Kimura, K.; Kamada, T.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 11, No. 3, 01.01.1991, p. 449-452.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hyperthermia-induced neuronal protection against ischemic injury in gerbils
AU - Kitagawa, K.
AU - Matsumoto, M.
AU - Tagaya, M.
AU - Kuwabara, K.
AU - Hata, Ryuji
AU - Handa, N.
AU - Fukunaga, R.
AU - Kimura, K.
AU - Kamada, T.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.
AB - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemia neuronal death.
UR - http://www.scopus.com/inward/record.url?scp=0025845010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025845010&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.1991.86
DO - 10.1038/jcbfm.1991.86
M3 - Article
VL - 11
SP - 449
EP - 452
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 3
ER -