Hyperthermia-induced neuronal protection against ischemic injury in gerbils

Kazuo Kitagawa; Masayasu Matsumoto; Masafumi Tagaya; Keisuke Kuwabara; Ryuji Hata; Nobuo Handa; Ryuzo Fukunaga; Kazufumi Kimura; Takenobu Kamada

Hyperthermia-induced neuronal protection against ischemic injury in gerbils

Kazuo Kitagawa, Masayasu Matsumoto, Masafumi Tagaya, Keisuke Kuwabara, Ryuji Hata, Nobuo Handa, Ryuzo Fukunaga, Kazufumi Kimura, Takenobu Kamada

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

Original language	English
Pages (from-to)	449-452
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	11
Issue number	3
Publication status	Published - 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

Cite this

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AU - Kitagawa, Kazuo

AU - Matsumoto, Masayasu

AU - Tagaya, Masafumi

AU - Kuwabara, Keisuke

AU - Hata, Ryuji

AU - Handa, Nobuo

AU - Fukunaga, Ryuzo

AU - Kimura, Kazufumi

AU - Kamada, Takenobu

PY - 1991

Y1 - 1991

N2 - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

AB - We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

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JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 3

ER -

Hyperthermia-induced neuronal protection against ischemic injury in gerbils

Abstract

All Science Journal Classification (ASJC) codes

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