Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Takayoshi Ubuka, Shogo Haraguchi, Yasuko Tobari, Misato Narihiro, Kei Ishikawa, Takanori Hayashi, Nobuhiro Harada, Kazuyoshi Tsutsui

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.

Original languageEnglish
Article number3061
JournalNature Communications
Volume5
DOIs
Publication statusPublished - 16-01-2014

Fingerprint

Gonadotropins
Sexual Behavior
Aromatase
hormones
Hormones
synthesis
Preoptic Area
morning
Birds
Neuropeptides
birds
estrogens
Androgens
secretions
evening
Quail
Estradiol
Brain
Estrogens
Demonstrations

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Ubuka, T., Haraguchi, S., Tobari, Y., Narihiro, M., Ishikawa, K., Hayashi, T., ... Tsutsui, K. (2014). Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. Nature Communications, 5, [3061]. https://doi.org/10.1038/ncomms4061
Ubuka, Takayoshi ; Haraguchi, Shogo ; Tobari, Yasuko ; Narihiro, Misato ; Ishikawa, Kei ; Hayashi, Takanori ; Harada, Nobuhiro ; Tsutsui, Kazuyoshi. / Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. In: Nature Communications. 2014 ; Vol. 5.
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Ubuka, T, Haraguchi, S, Tobari, Y, Narihiro, M, Ishikawa, K, Hayashi, T, Harada, N & Tsutsui, K 2014, 'Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis', Nature Communications, vol. 5, 3061. https://doi.org/10.1038/ncomms4061

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. / Ubuka, Takayoshi; Haraguchi, Shogo; Tobari, Yasuko; Narihiro, Misato; Ishikawa, Kei; Hayashi, Takanori; Harada, Nobuhiro; Tsutsui, Kazuyoshi.

In: Nature Communications, Vol. 5, 3061, 16.01.2014.

Research output: Contribution to journalArticle

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