TY - JOUR
T1 - Hypothermia attenuates the severity of oxidative stress development in asphyxiated newborns
AU - Kakita, Hiroki
AU - Hussein, Mohamed Hamed
AU - Kato, Shin
AU - Yamada, Yasumasa
AU - Nagaya, Yoshiaki
AU - Asai, Hayato
AU - Goto, Tatenobu
AU - Ito, Koichi
AU - Sugiura, Tokio
AU - Daoud, Ghada Abdel Hamid
AU - Ito, Tetsuya
AU - Kato, Ineko
AU - Togari, Hajime
PY - 2012/10
Y1 - 2012/10
N2 - Purpose: This retrospective case-control study aimed to examine the development of oxidative stress in asphyxiated infants delivered at more than 37 weeks of gestation. Material and Methods: Thirty-seven neonates were stratified into 3 groups: the first group experienced hypothermia (n = 6); the second received hypothermia cooling cup treatment for 3 days, normothermia (n = 16); and the third was the control group (n = 15).Serum total hydroperoxide (TH), biological antioxidant potential, and oxidative stress index (OSI) (calculated as TH/biological antioxidant potential) were measured within 3 hours after birth. Results: Serum TH and OSI levels gradually increased after birth in hypothermia and normothermia cases. At all time points, serum TH and OSI levels were higher in hypothermia and normothermia cases than in control cases. Serum TH and OSI levels were higher in normothermia cases than in hypothermia cases at days 3, 5, and 7. Conclusion: This study demonstrated that hypothermia attenuated the development of systemic oxidative stress in asphyxiated newborns.
AB - Purpose: This retrospective case-control study aimed to examine the development of oxidative stress in asphyxiated infants delivered at more than 37 weeks of gestation. Material and Methods: Thirty-seven neonates were stratified into 3 groups: the first group experienced hypothermia (n = 6); the second received hypothermia cooling cup treatment for 3 days, normothermia (n = 16); and the third was the control group (n = 15).Serum total hydroperoxide (TH), biological antioxidant potential, and oxidative stress index (OSI) (calculated as TH/biological antioxidant potential) were measured within 3 hours after birth. Results: Serum TH and OSI levels gradually increased after birth in hypothermia and normothermia cases. At all time points, serum TH and OSI levels were higher in hypothermia and normothermia cases than in control cases. Serum TH and OSI levels were higher in normothermia cases than in hypothermia cases at days 3, 5, and 7. Conclusion: This study demonstrated that hypothermia attenuated the development of systemic oxidative stress in asphyxiated newborns.
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U2 - 10.1016/j.jcrc.2011.12.013
DO - 10.1016/j.jcrc.2011.12.013
M3 - Article
C2 - 22361164
AN - SCOPUS:84867331011
SN - 0883-9441
VL - 27
SP - 469
EP - 473
JO - Journal of Critical Care
JF - Journal of Critical Care
IS - 5
ER -