"Hypothesis of seven balances": Molecular mechanisms behind alcoholic liver diseases and association with PPARα

Takashi Moriya, Hisao Naito, Yuki Ito, Tamie Nakajima

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

"Hypothesis of Seven Balances": Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPARα: Takashi MORIYA, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Objectives: The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated receptor α (PPARα), which has important roles in fatty acid oxidation, oxidative stress, inflammatory responses, and possibly liver fibrosis. Methods: We conducted an extensive literature review of over a hundred publications and collated the findings with evidence generated in our laboratory. Results: Our research points to a working hypothesis of seven balances for alcoholic liver diseases consisting of: 1) ethanol oxidation balance in hepatocytes; 2) PPARα activities in liver; 3) fatty acid metabolism balance in hepatic mitochondria; 4) gastrointestinal response to ethanol, acetaldehyde and lipopolysaccharide (LPS); 5) Kupffer cells response to LPS, oxidative stress and inflammatory cytokines; 6) adiponectin levels in plasma interchangeably regulated by tumor necrosis factor-α (TNF-α); and 7) stellate cells response to all of the above promoting hepatic fibrosis. Cellular mechanisms behind alcoholic liver diseases reveal close temporal associations of PPARα, adiponectin, TNF-α, cellular inflammation, proliferation, and potentially fibrosis as illustrated in "the hypothesis of seven balances." Conclusions: The regulation and adjustment of PPARα activation underlying the balance of molecular cascades might resolve the progression of alcoholic liver diseases by reducing oxidative stress and inflammatory effects induced by nuclear factor-κB as well as the associated adiponectin pathway. Further elucidation of these pathways would reveal exciting new prospects for treating alcoholic liver diseases and other related liver disorders.

Original languageEnglish
Pages (from-to)391-403
Number of pages13
JournalJournal of Occupational Health
Volume51
Issue number5
DOIs
Publication statusPublished - 01-09-2009

Fingerprint

Alcoholic Liver Diseases
Peroxisome Proliferator-Activated Receptors
Adiponectin
Oxidative Stress
Liver
Lipopolysaccharides
Fibrosis
Ethanol
Fatty Acids
Tumor Necrosis Factor-alpha
Kupffer Cells
Acetaldehyde
Environmental Health
Occupational Health
Liver Cirrhosis
Publications
Hepatocytes
Mitochondria
Cell Proliferation
Medicine

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Public Health, Environmental and Occupational Health

Cite this

@article{281846ab9dff4e8ea5696122a398193e,
title = "{"}Hypothesis of seven balances{"}: Molecular mechanisms behind alcoholic liver diseases and association with PPARα",
abstract = "{"}Hypothesis of Seven Balances{"}: Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPARα: Takashi MORIYA, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Objectives: The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working {"}hypothesis of seven balances{"} in relation to peroxisome proliferator activated receptor α (PPARα), which has important roles in fatty acid oxidation, oxidative stress, inflammatory responses, and possibly liver fibrosis. Methods: We conducted an extensive literature review of over a hundred publications and collated the findings with evidence generated in our laboratory. Results: Our research points to a working hypothesis of seven balances for alcoholic liver diseases consisting of: 1) ethanol oxidation balance in hepatocytes; 2) PPARα activities in liver; 3) fatty acid metabolism balance in hepatic mitochondria; 4) gastrointestinal response to ethanol, acetaldehyde and lipopolysaccharide (LPS); 5) Kupffer cells response to LPS, oxidative stress and inflammatory cytokines; 6) adiponectin levels in plasma interchangeably regulated by tumor necrosis factor-α (TNF-α); and 7) stellate cells response to all of the above promoting hepatic fibrosis. Cellular mechanisms behind alcoholic liver diseases reveal close temporal associations of PPARα, adiponectin, TNF-α, cellular inflammation, proliferation, and potentially fibrosis as illustrated in {"}the hypothesis of seven balances.{"} Conclusions: The regulation and adjustment of PPARα activation underlying the balance of molecular cascades might resolve the progression of alcoholic liver diseases by reducing oxidative stress and inflammatory effects induced by nuclear factor-κB as well as the associated adiponectin pathway. Further elucidation of these pathways would reveal exciting new prospects for treating alcoholic liver diseases and other related liver disorders.",
author = "Takashi Moriya and Hisao Naito and Yuki Ito and Tamie Nakajima",
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"Hypothesis of seven balances" : Molecular mechanisms behind alcoholic liver diseases and association with PPARα. / Moriya, Takashi; Naito, Hisao; Ito, Yuki; Nakajima, Tamie.

In: Journal of Occupational Health, Vol. 51, No. 5, 01.09.2009, p. 391-403.

Research output: Contribution to journalReview article

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T2 - Molecular mechanisms behind alcoholic liver diseases and association with PPARα

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AU - Nakajima, Tamie

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N2 - "Hypothesis of Seven Balances": Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPARα: Takashi MORIYA, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Objectives: The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated receptor α (PPARα), which has important roles in fatty acid oxidation, oxidative stress, inflammatory responses, and possibly liver fibrosis. Methods: We conducted an extensive literature review of over a hundred publications and collated the findings with evidence generated in our laboratory. Results: Our research points to a working hypothesis of seven balances for alcoholic liver diseases consisting of: 1) ethanol oxidation balance in hepatocytes; 2) PPARα activities in liver; 3) fatty acid metabolism balance in hepatic mitochondria; 4) gastrointestinal response to ethanol, acetaldehyde and lipopolysaccharide (LPS); 5) Kupffer cells response to LPS, oxidative stress and inflammatory cytokines; 6) adiponectin levels in plasma interchangeably regulated by tumor necrosis factor-α (TNF-α); and 7) stellate cells response to all of the above promoting hepatic fibrosis. Cellular mechanisms behind alcoholic liver diseases reveal close temporal associations of PPARα, adiponectin, TNF-α, cellular inflammation, proliferation, and potentially fibrosis as illustrated in "the hypothesis of seven balances." Conclusions: The regulation and adjustment of PPARα activation underlying the balance of molecular cascades might resolve the progression of alcoholic liver diseases by reducing oxidative stress and inflammatory effects induced by nuclear factor-κB as well as the associated adiponectin pathway. Further elucidation of these pathways would reveal exciting new prospects for treating alcoholic liver diseases and other related liver disorders.

AB - "Hypothesis of Seven Balances": Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPARα: Takashi MORIYA, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Objectives: The purpose of this review to collate current leading scientific advances of molecular mechanisms in alcoholic liver diseases and to propose a working "hypothesis of seven balances" in relation to peroxisome proliferator activated receptor α (PPARα), which has important roles in fatty acid oxidation, oxidative stress, inflammatory responses, and possibly liver fibrosis. Methods: We conducted an extensive literature review of over a hundred publications and collated the findings with evidence generated in our laboratory. Results: Our research points to a working hypothesis of seven balances for alcoholic liver diseases consisting of: 1) ethanol oxidation balance in hepatocytes; 2) PPARα activities in liver; 3) fatty acid metabolism balance in hepatic mitochondria; 4) gastrointestinal response to ethanol, acetaldehyde and lipopolysaccharide (LPS); 5) Kupffer cells response to LPS, oxidative stress and inflammatory cytokines; 6) adiponectin levels in plasma interchangeably regulated by tumor necrosis factor-α (TNF-α); and 7) stellate cells response to all of the above promoting hepatic fibrosis. Cellular mechanisms behind alcoholic liver diseases reveal close temporal associations of PPARα, adiponectin, TNF-α, cellular inflammation, proliferation, and potentially fibrosis as illustrated in "the hypothesis of seven balances." Conclusions: The regulation and adjustment of PPARα activation underlying the balance of molecular cascades might resolve the progression of alcoholic liver diseases by reducing oxidative stress and inflammatory effects induced by nuclear factor-κB as well as the associated adiponectin pathway. Further elucidation of these pathways would reveal exciting new prospects for treating alcoholic liver diseases and other related liver disorders.

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