Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment

Atsushi Suzuki, Motoko Kotake, Yasunaga Ono, Taiya Kato, Naohisa Oda, Nobuki Hayakawa, Shuji Hashimoto, Mitsuyasu Itoh

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Abstract

The prevalence of hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of hypovitaminosis D (<20 ng/ml) was 70.6%. Serum concentrations of 25-OHD were associated with HbA1c (P = 0.013), age (P = 0.070) and serum albumin (P<0.001), but were not related to BMI or the duration of diabetes. The levels of 25-OHD were significantly lower in the population with apparent microvascular complications, although serum creatinine levels were below 2.0 mg/dl. Serum 25-OHD concentrations in the group treated with insulin (15.4 ± 6.5 ng/ml) was lower than those in the patients treated with diet alone (20.8 ± 7.6 ng/ml) and with oral hypoglycemic agents (17.3 ± 7.0 ng/ml). Furthermore, the highest incidence of osteoporotic fracture and/or back deformity was observed in insulin-treated patients with hypovitaminosis D. In conclusion, these results suggest that microvascular complications and insulin treatment in type 2 diabetes patients are associated with the co-existence of hypovitaminosis D, and that hypovitaminosis D in insulin-treated patients is possibly related to the risk of osteoporotic fracture.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalEndocrine Journal
Volume53
Issue number4
DOIs
Publication statusPublished - 14-09-2006

Fingerprint

Type 2 Diabetes Mellitus
Insulin
Serum
Osteoporotic Fractures
Therapeutics
Hypoglycemic Agents
Serum Albumin
Population
Osteoporosis
Observational Studies
Creatinine
Diet
Incidence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Suzuki, Atsushi ; Kotake, Motoko ; Ono, Yasunaga ; Kato, Taiya ; Oda, Naohisa ; Hayakawa, Nobuki ; Hashimoto, Shuji ; Itoh, Mitsuyasu. / Hypovitaminosis D in type 2 diabetes mellitus : Association with microvascular complications and type of treatment. In: Endocrine Journal. 2006 ; Vol. 53, No. 4. pp. 503-510.
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abstract = "The prevalence of hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of hypovitaminosis D (<20 ng/ml) was 70.6{\%}. Serum concentrations of 25-OHD were associated with HbA1c (P = 0.013), age (P = 0.070) and serum albumin (P<0.001), but were not related to BMI or the duration of diabetes. The levels of 25-OHD were significantly lower in the population with apparent microvascular complications, although serum creatinine levels were below 2.0 mg/dl. Serum 25-OHD concentrations in the group treated with insulin (15.4 ± 6.5 ng/ml) was lower than those in the patients treated with diet alone (20.8 ± 7.6 ng/ml) and with oral hypoglycemic agents (17.3 ± 7.0 ng/ml). Furthermore, the highest incidence of osteoporotic fracture and/or back deformity was observed in insulin-treated patients with hypovitaminosis D. In conclusion, these results suggest that microvascular complications and insulin treatment in type 2 diabetes patients are associated with the co-existence of hypovitaminosis D, and that hypovitaminosis D in insulin-treated patients is possibly related to the risk of osteoporotic fracture.",
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Hypovitaminosis D in type 2 diabetes mellitus : Association with microvascular complications and type of treatment. / Suzuki, Atsushi; Kotake, Motoko; Ono, Yasunaga; Kato, Taiya; Oda, Naohisa; Hayakawa, Nobuki; Hashimoto, Shuji; Itoh, Mitsuyasu.

In: Endocrine Journal, Vol. 53, No. 4, 14.09.2006, p. 503-510.

Research output: Contribution to journalArticle

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T1 - Hypovitaminosis D in type 2 diabetes mellitus

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AU - Suzuki, Atsushi

AU - Kotake, Motoko

AU - Ono, Yasunaga

AU - Kato, Taiya

AU - Oda, Naohisa

AU - Hayakawa, Nobuki

AU - Hashimoto, Shuji

AU - Itoh, Mitsuyasu

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N2 - The prevalence of hypovitaminosis D has been recently reevaluated, and diabetes is considered as a risk factor for osteoporosis. We studied the association of the prevalence of hypovitaminosis D with the clinical features of diabetes. We conducted the observational study in 581 Japanese patients with type 2 diabetes mellitus and 51 normal subjects, and analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with type 2 diabetes. Mean serum 25-OHD concentration in type 2 diabetes patients was 17.0 ± 7.1 ng/ml (Mean ± SD) in winter, and was not statistically different from normal population (17.5 ± 3.6 ng/ml). The prevalence of hypovitaminosis D (<20 ng/ml) was 70.6%. Serum concentrations of 25-OHD were associated with HbA1c (P = 0.013), age (P = 0.070) and serum albumin (P<0.001), but were not related to BMI or the duration of diabetes. The levels of 25-OHD were significantly lower in the population with apparent microvascular complications, although serum creatinine levels were below 2.0 mg/dl. Serum 25-OHD concentrations in the group treated with insulin (15.4 ± 6.5 ng/ml) was lower than those in the patients treated with diet alone (20.8 ± 7.6 ng/ml) and with oral hypoglycemic agents (17.3 ± 7.0 ng/ml). Furthermore, the highest incidence of osteoporotic fracture and/or back deformity was observed in insulin-treated patients with hypovitaminosis D. In conclusion, these results suggest that microvascular complications and insulin treatment in type 2 diabetes patients are associated with the co-existence of hypovitaminosis D, and that hypovitaminosis D in insulin-treated patients is possibly related to the risk of osteoporotic fracture.

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