TY - JOUR
T1 - Identification and characterization of a human G9P[23] rotavirus strain from a child with diarrhoea in Thailand
T2 - Evidence for porcine-to-human interspecies transmission
AU - Komoto, Satoshi
AU - Tacharoenmuang, Ratana
AU - Guntapong, Ratigorn
AU - Ide, Tomihiko
AU - Sinchai, Phakapun
AU - Upachai, Sompong
AU - Fukuda, Saori
AU - Yoshikawa, Tetsushi
AU - Tharmaphornpilas, Piyanit
AU - Sangkitporn, Somchai
AU - Taniguchi, Koki
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017/4
Y1 - 2017/4
N2 - An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8- N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
AB - An unusual rotavirus strain with the G9P[23] genotype (RVA/Human-wt/THA/KKL-117/2014/G9P[23]) was identified in a stool specimen from a 10-month-old child hospitalized with severe diarrhoea. In this study, we sequenced and characterized the complete genome of strain KKL-117. On full-genomic analysis, strain KKL-117 was found to have the following genotype constellation: G9-P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The non-G/P genotype constellation of this strain (I5-R1-C1-M1-A8- N1-T1-E1-H1) is commonly shared with rotavirus strains from pigs. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain KKL-117 appeared to be of porcine origin. Our observations provide important insights into the dynamic interactions between human and porcine rotavirus strains.
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U2 - 10.1099/jgv.0.000722
DO - 10.1099/jgv.0.000722
M3 - Article
C2 - 28382902
AN - SCOPUS:85019123683
SN - 0022-1317
VL - 98
SP - 532
EP - 538
JO - Journal of General Virology
JF - Journal of General Virology
IS - 4
ER -
