Identification and characterization of cancer stem cells in ovarian yolk sac tumors

Shiro Suzuki, Mikio Terauchi, Tomokazu Umezu, Hiroaki Kajiyama, Kiyosumi Shibata, Akihiro Nawa, Fumitaka Kikkawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Recent evidence supports the cancer stem cell theory, that is, that malignant tumors arise from cells termed cancer stem cells or tumor-initiating cells that have the ability to self-renew and are responsible for maintaining the tumor. Cells with marked tumor-initiating capacity have recently been identified in a number of solid tumors. CD133 (PROM1, human prominin-1) has been used as a marker to detect stem cells (progenitor cells) and cancer stem cells (tumor-initiating cells) in various tissues. Ovarian yolk sac tumors (YSTs) are rare and highly malignant. The present study was designed to evaluate the tumor-forming ability of CD133+ cells in ovarian YST cell lines and to examine the characteristics of CD133+ cells, such as cell growth and invasiveness. Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133.

Original languageEnglish
Pages (from-to)2179-2185
Number of pages7
JournalCancer science
Issue number10
Publication statusPublished - 10-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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