Identification and characterization of cancer stem cells in ovarian yolk sac tumors

Shiro Suzuki; Mikio Terauchi; Tomokazu Umezu; Hiroaki Kajiyama; Kiyosumi Shibata; Akihiro Nawa; Fumitaka Kikkawa

doi:10.1111/j.1349-7006.2010.01672.x

Identification and characterization of cancer stem cells in ovarian yolk sac tumors

Shiro Suzuki, Mikio Terauchi, Tomokazu Umezu, Hiroaki Kajiyama, Kiyosumi Shibata, Akihiro Nawa, Fumitaka Kikkawa

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Recent evidence supports the cancer stem cell theory, that is, that malignant tumors arise from cells termed cancer stem cells or tumor-initiating cells that have the ability to self-renew and are responsible for maintaining the tumor. Cells with marked tumor-initiating capacity have recently been identified in a number of solid tumors. CD133 (PROM1, human prominin-1) has been used as a marker to detect stem cells (progenitor cells) and cancer stem cells (tumor-initiating cells) in various tissues. Ovarian yolk sac tumors (YSTs) are rare and highly malignant. The present study was designed to evaluate the tumor-forming ability of CD133⁺ cells in ovarian YST cell lines and to examine the characteristics of CD133⁺ cells, such as cell growth and invasiveness. Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133.

Original language	English
Pages (from-to)	2179-2185
Number of pages	7
Journal	Cancer science
Volume	101
Issue number	10
DOIs	https://doi.org/10.1111/j.1349-7006.2010.01672.x
Publication status	Published - 10-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2010.01672.x

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title = "Identification and characterization of cancer stem cells in ovarian yolk sac tumors",

abstract = "Recent evidence supports the cancer stem cell theory, that is, that malignant tumors arise from cells termed cancer stem cells or tumor-initiating cells that have the ability to self-renew and are responsible for maintaining the tumor. Cells with marked tumor-initiating capacity have recently been identified in a number of solid tumors. CD133 (PROM1, human prominin-1) has been used as a marker to detect stem cells (progenitor cells) and cancer stem cells (tumor-initiating cells) in various tissues. Ovarian yolk sac tumors (YSTs) are rare and highly malignant. The present study was designed to evaluate the tumor-forming ability of CD133+ cells in ovarian YST cell lines and to examine the characteristics of CD133+ cells, such as cell growth and invasiveness. Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133.",

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AU - Suzuki, Shiro

AU - Terauchi, Mikio

AU - Umezu, Tomokazu

AU - Kajiyama, Hiroaki

AU - Shibata, Kiyosumi

AU - Nawa, Akihiro

AU - Kikkawa, Fumitaka

PY - 2010/10

Y1 - 2010/10

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Identification and characterization of cancer stem cells in ovarian yolk sac tumors

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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