Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene

Keiichiro Hashimoto, Momoki Hirai, Yoshikazu Kurosawa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Recently, a novel human major histocompatibility complex (MHC) class I-like gene (HLA-H) was reported as a candidate gene for human hereditary haemochromatosis, a recessive disease of iron metabolism with a remarkably high incidence in northern Europeans. Independently we have isolated this gene in the course of a search for new human MHC class I-related genes and named it MR2. Here we report a mouse homolog of this human gene. The mouse MR2 gene is similar to the human counterpart with an overall predicted amino acid sequence similarity of ~ 66% and it is expressed in various tissues as in human. The extra eight amino acid residues between the α1 and the α2 domains in the mouse molecule compared to the human counterpart can be explained by the creation of the coding sequence from the intron. While the human gene is located at the site telomeric to the MHC region on human chromosome 6, our study indicated the translocation of the mouse homolog from the site telomeric to the MHC on mouse chromosome 17 to chromosome 13 along with other genes. This mouse gene should be important in clarifying a possible role in iron metabolism.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume230
Issue number1
DOIs
Publication statusPublished - 03-01-1997

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Hemochromatosis
Genes
Major Histocompatibility Complex
Chromosomes
MHC Class I Genes
Metabolism
Iron
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Amino Acids
Human Chromosomes
Introns
Amino Acid Sequence
Tissue
Incidence
Molecules

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene. / Hashimoto, Keiichiro; Hirai, Momoki; Kurosawa, Yoshikazu.

In: Biochemical and Biophysical Research Communications, Vol. 230, No. 1, 03.01.1997, p. 35-39.

Research output: Contribution to journalArticle

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