Abstract
We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
| Original language | English |
|---|---|
| Pages (from-to) | 217-220 |
| Number of pages | 4 |
| Journal | Molecular Brain Research |
| Volume | 58 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 15-07-1998 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cellular and Molecular Neuroscience
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Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers. / Iwata, Nakao; Virkkunen, Matti; Linnoila, Markku; Goldman, David.
In: Molecular Brain Research, Vol. 58, No. 1-2, 15.07.1998, p. 217-220.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers
AU - Iwata, Nakao
AU - Virkkunen, Matti
AU - Linnoila, Markku
AU - Goldman, David
PY - 1998/7/15
Y1 - 1998/7/15
N2 - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
AB - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
UR - http://www.scopus.com/inward/record.url?scp=0032528319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032528319&partnerID=8YFLogxK
U2 - 10.1016/S0169-328X(98)00111-9
DO - 10.1016/S0169-328X(98)00111-9
M3 - Article
C2 - 9685650
AN - SCOPUS:0032528319
VL - 58
SP - 217
EP - 220
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -