Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata; Matti Virkkunen; Markku Linnoila; David Goldman

doi:10.1016/S0169-328X(98)00111-9

Identification of a naturally occurring Pro₁₅-Ser₁₅ substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata, Matti Virkkunen, Markku Linnoila, David Goldman

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Molecular Brain Research
Volume	58
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(98)00111-9
Publication status	Published - 15-07-1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(98)00111-9

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Iwata, N., Virkkunen, M., Linnoila, M., & Goldman, D. (1998). Identification of a naturally occurring Pro₁₅-Ser₁₅ substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers. Molecular Brain Research, 58(1-2), 217-220. https://doi.org/10.1016/S0169-328X(98)00111-9

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