Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata; Matti Virkkunen; Markku Linnoila; David Goldman

doi:10.1016/S0169-328X(98)00111-9

Identification of a naturally occurring Pro₁₅-Ser₁₅ substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata, Matti Virkkunen, Markku Linnoila, David Goldman

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Molecular Brain Research
Volume	58
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(98)00111-9
Publication status	Published - 15-07-1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(98)00111-9

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title = "Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers",

abstract = "We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).",

author = "Nakao Iwata and Matti Virkkunen and Markku Linnoila and David Goldman",

note = "Funding Information: The work of Nakao Iwata was partly supported by the Research Grant (9B-5) for Nervous and Mental Disorders from the Ministry of Health and Welfare of Japan. We would like to thank Longina Akhtar for preparation and maintenance of lymphoblastoid cell lines. We also appreciate helpful discussions with Jaakko Lappalainen. ",

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doi = "10.1016/S0169-328X(98)00111-9",

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T1 - Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

AU - Iwata, Nakao

AU - Virkkunen, Matti

AU - Linnoila, Markku

AU - Goldman, David

N1 - Funding Information: The work of Nakao Iwata was partly supported by the Research Grant (9B-5) for Nervous and Mental Disorders from the Ministry of Health and Welfare of Japan. We would like to thank Longina Akhtar for preparation and maintenance of lymphoblastoid cell lines. We also appreciate helpful discussions with Jaakko Lappalainen.

PY - 1998/7/15

Y1 - 1998/7/15

N2 - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

AB - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

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Identification of a naturally occurring Pro₁₅-Ser₁₅ substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Abstract

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