TY - JOUR
T1 - Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers
AU - Iwata, Nakao
AU - Virkkunen, Matti
AU - Linnoila, Markku
AU - Goldman, David
N1 - Funding Information:
The work of Nakao Iwata was partly supported by the Research Grant (9B-5) for Nervous and Mental Disorders from the Ministry of Health and Welfare of Japan. We would like to thank Longina Akhtar for preparation and maintenance of lymphoblastoid cell lines. We also appreciate helpful discussions with Jaakko Lappalainen.
PY - 1998/7/15
Y1 - 1998/7/15
N2 - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
AB - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
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U2 - 10.1016/S0169-328X(98)00111-9
DO - 10.1016/S0169-328X(98)00111-9
M3 - Article
C2 - 9685650
AN - SCOPUS:0032528319
SN - 0006-8993
VL - 58
SP - 217
EP - 220
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -