Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers

Nakao Iwata, Matti Virkkunen, Markku Linnoila, David Goldman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalMolecular Brain Research
Volume58
Issue number1-2
DOIs
Publication statusPublished - 15-07-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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