TY - JOUR
T1 - Identification of a naturally occurring Pro15-Ser15 substitution in the serotonin(5A) receptor gene in alcoholics and healthy volunteers
AU - Iwata, Nakao
AU - Virkkunen, Matti
AU - Linnoila, Markku
AU - Goldman, David
PY - 1998/7/15
Y1 - 1998/7/15
N2 - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
AB - We screened the serotonin(5A) receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively (p = n.s.).
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U2 - 10.1016/S0169-328X(98)00111-9
DO - 10.1016/S0169-328X(98)00111-9
M3 - Article
C2 - 9685650
AN - SCOPUS:0032528319
VL - 58
SP - 217
EP - 220
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -