Identification of a neuronal cell surface molecule, plexin, in mice

Toshiki Kameyama, Yasunori Murakami, Fumikazu Suto, Atsushi Kawakami, Shin Takagi, Tatsumi Hirata, Hajime Fujisawa

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Abstract

We searched for mouse homologues of the cell adhesion protein plexin which was originally found in Xenopus, and obtained a cDNA encoding a plexin-like protein. We referred to this protein as mouse plexin 1. The overall amino acid identity between mouse plexin 1 and Xenopus plexin was 84%. As in the Xenopus plexin, the extracellular segment of mouse plexin 1 protein possessed three cysteine-rich domains which showed significant homology with the cysteine-rich domain of the c-Met proto-oncogene protein product (c-Met protein) and Met-like receptor protein tyrosine kinases. Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume226
Issue number2
DOIs
Publication statusPublished - 13-09-1996

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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