Identification of a neuronal cell surface molecule, plexin, in mice

Toshiki Kameyama, Yasunori Murakami, Fumikazu Suto, Atsushi Kawakami, Shin Takagi, Tatsumi Hirata, Hajime Fujisawa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We searched for mouse homologues of the cell adhesion protein plexin which was originally found in Xenopus, and obtained a cDNA encoding a plexin-like protein. We referred to this protein as mouse plexin 1. The overall amino acid identity between mouse plexin 1 and Xenopus plexin was 84%. As in the Xenopus plexin, the extracellular segment of mouse plexin 1 protein possessed three cysteine-rich domains which showed significant homology with the cysteine-rich domain of the c-Met proto-oncogene protein product (c-Met protein) and Met-like receptor protein tyrosine kinases. Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume226
Issue number2
DOIs
Publication statusPublished - 13-09-1996

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Molecules
Xenopus
Cysteine
Proteins
Proto-Oncogene Proteins c-met
Proto-Oncogenes
plexin
Oncogene Proteins
Cell adhesion
Receptor Protein-Tyrosine Kinases
Cell Adhesion
Northern Blotting
Brain
Complementary DNA
Amino Acids

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kameyama, Toshiki ; Murakami, Yasunori ; Suto, Fumikazu ; Kawakami, Atsushi ; Takagi, Shin ; Hirata, Tatsumi ; Fujisawa, Hajime. / Identification of a neuronal cell surface molecule, plexin, in mice. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 226, No. 2. pp. 524-529.
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Kameyama, T, Murakami, Y, Suto, F, Kawakami, A, Takagi, S, Hirata, T & Fujisawa, H 1996, 'Identification of a neuronal cell surface molecule, plexin, in mice', Biochemical and Biophysical Research Communications, vol. 226, no. 2, pp. 524-529. https://doi.org/10.1006/bbrc.1996.1388

Identification of a neuronal cell surface molecule, plexin, in mice. / Kameyama, Toshiki; Murakami, Yasunori; Suto, Fumikazu; Kawakami, Atsushi; Takagi, Shin; Hirata, Tatsumi; Fujisawa, Hajime.

In: Biochemical and Biophysical Research Communications, Vol. 226, No. 2, 13.09.1996, p. 524-529.

Research output: Contribution to journalArticle

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