TY - JOUR
T1 - Identification of a shark sequence resembling the major histocompatibility complex class I α3 domain
AU - Hashimoto, K.
AU - Nakanishi, T.
AU - Kurosawa, Y.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - Elasmobranchs (sharks and rays) branched off from the vertebrate line leading to the mammals more than 400 million years ago. They do not exhibit acute allograft rejection, and so far no report has pointed to the presence of major histocompatibility complex (MHC) antigen-like molecules in elasmobranchs. Here we demonstrate the existence of a gene in the shark (Triakis scyllia) genome with a sequence that resembles the MHC class I α3 domains of other vertebrates. Several amino acids considered to be important for the interaction of the T-cell coreceptor CD8 with the MHC class I α3 domain are conserved in the shark sequence.
AB - Elasmobranchs (sharks and rays) branched off from the vertebrate line leading to the mammals more than 400 million years ago. They do not exhibit acute allograft rejection, and so far no report has pointed to the presence of major histocompatibility complex (MHC) antigen-like molecules in elasmobranchs. Here we demonstrate the existence of a gene in the shark (Triakis scyllia) genome with a sequence that resembles the MHC class I α3 domains of other vertebrates. Several amino acids considered to be important for the interaction of the T-cell coreceptor CD8 with the MHC class I α3 domain are conserved in the shark sequence.
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U2 - 10.1073/pnas.89.6.2209
DO - 10.1073/pnas.89.6.2209
M3 - Article
C2 - 1549583
AN - SCOPUS:0026509498
SN - 0027-8424
VL - 89
SP - 2209
EP - 2212
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 6
ER -