TY - JOUR
T1 - Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis Application to cases from rubber gloves
AU - Kaniwa, Masa‐aki ‐a
AU - Isama, Kazuo
AU - Nakamura, Akitada
AU - Kantoh, Hiromi
AU - Hosono, Kumiko
AU - Itoh, Masatoshi
AU - Shibata, Keiko
AU - Usuda, Toshikazu
AU - Asahi, Kunihiko
AU - Osada, Tomoko
AU - Matsunaga, Kayoko
AU - Ueda, Hiroshi
PY - 1994/8
Y1 - 1994/8
N2 - 5 cases of allergic contact dermatitis from rubber gloves were investigated by our recommended procedures using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high‐performance liquid chromatography (HPLC). We previously confirmed that zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamae‐type accelerator (DTC), was causative in a case of allergic contact dermatitis from rubber work gloves. Subsequently, we have clarified that DTCs such as zinc dimethyldithiocarbamate (ZDMC), zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) and amines such as dimethylamine (DMA), diethylamine (DEA) and piperidine (PIP) were also causative in cases from surgical rubber gloves. Thus, our investigative studies revealed that, although thiurams have been taken much more notice of as allergenic compounds than their corresponding DTCs and amines, not only DTCs such as ZDMC, ZDEC, ZDBC and ZEPC, but also amines such as DMA, DEA and PIP were noteworthy causative candidates of allergic contact dermatitis from rubber gloves.
AB - 5 cases of allergic contact dermatitis from rubber gloves were investigated by our recommended procedures using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high‐performance liquid chromatography (HPLC). We previously confirmed that zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamae‐type accelerator (DTC), was causative in a case of allergic contact dermatitis from rubber work gloves. Subsequently, we have clarified that DTCs such as zinc dimethyldithiocarbamate (ZDMC), zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) and amines such as dimethylamine (DMA), diethylamine (DEA) and piperidine (PIP) were also causative in cases from surgical rubber gloves. Thus, our investigative studies revealed that, although thiurams have been taken much more notice of as allergenic compounds than their corresponding DTCs and amines, not only DTCs such as ZDMC, ZDEC, ZDBC and ZEPC, but also amines such as DMA, DEA and PIP were noteworthy causative candidates of allergic contact dermatitis from rubber gloves.
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U2 - 10.1111/j.1600-0536.1994.tb01920.x
DO - 10.1111/j.1600-0536.1994.tb01920.x
M3 - Article
C2 - 7750271
AN - SCOPUS:0028359347
SN - 0105-1873
VL - 31
SP - 65
EP - 71
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 2
ER -