Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis Application to cases from rubber gloves

Masa‐aki ‐a Kaniwa, Kazuo Isama, Akitada Nakamura, Hiromi Kantoh, Kumiko Hosono, Masatoshi Itoh, Keiko Shibata, Toshikazu Usuda, Kunihiko Asahi, Tomoko Osada, Kayoko Matsunaga, Hiroshi Ueda

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

5 cases of allergic contact dermatitis from rubber gloves were investigated by our recommended procedures using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high‐performance liquid chromatography (HPLC). We previously confirmed that zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamae‐type accelerator (DTC), was causative in a case of allergic contact dermatitis from rubber work gloves. Subsequently, we have clarified that DTCs such as zinc dimethyldithiocarbamate (ZDMC), zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) and amines such as dimethylamine (DMA), diethylamine (DEA) and piperidine (PIP) were also causative in cases from surgical rubber gloves. Thus, our investigative studies revealed that, although thiurams have been taken much more notice of as allergenic compounds than their corresponding DTCs and amines, not only DTCs such as ZDMC, ZDEC, ZDBC and ZEPC, but also amines such as DMA, DEA and PIP were noteworthy causative candidates of allergic contact dermatitis from rubber gloves.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalContact Dermatitis
Volume31
Issue number2
DOIs
Publication statusPublished - 08-1994

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

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