Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored blaOXA-160, bla OXA-72, and blaOXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of blaOXA-160 and bla OXA-40 beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases