Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania

Guo Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong Ning Wang, Yohei Doi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored blaOXA-160, bla OXA-72, and blaOXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of blaOXA-160 and bla OXA-40 beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.

Original languageEnglish
Pages (from-to)429-432
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number1
DOIs
Publication statusPublished - 01-2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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