TY - JOUR
T1 - Identification of diverse OXA-40 group carbapenemases, including a novel variant, OXA-160, from Acinetobacter baumannii in Pennsylvania
AU - Tian, Guo Bao
AU - Adams-Haduch, Jennifer M.
AU - Bogdanovich, Tatiana
AU - Pasculle, Anthony W.
AU - Quinn, John P.
AU - Wang, Hong Ning
AU - Doi, Yohei
PY - 2011/1
Y1 - 2011/1
N2 - Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored blaOXA-160, bla OXA-72, and blaOXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of blaOXA-160 and bla OXA-40 beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.
AB - Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored blaOXA-160, bla OXA-72, and blaOXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of blaOXA-160 and bla OXA-40 beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.
UR - http://www.scopus.com/inward/record.url?scp=78650658424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650658424&partnerID=8YFLogxK
U2 - 10.1128/AAC.01155-10
DO - 10.1128/AAC.01155-10
M3 - Article
C2 - 21041501
AN - SCOPUS:78650658424
SN - 0066-4804
VL - 55
SP - 429
EP - 432
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 1
ER -
