Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology