Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Hiroaki Korekane; Jong Yi Park; Akio Matsumoto; Kazuki Nakajima; Shinji Takamatsu; Kazuaki Ohtsubo; Yasuhide Miyamoto; Shinya Hanashima; Kenji Kanekiyo; Shinobu Kitazume; Yoshiki Yamaguchi; Ichiro Matsuo; Naoyuki Taniguchi

doi:10.1074/jbc.M113.474304

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

Hiroaki Korekane
, Jong Yi Park
, Akio Matsumoto
, Kazuki Nakajima
, Shinji Takamatsu
, Kazuaki Ohtsubo
, Yasuhide Miyamoto
, Shinya Hanashima
, Kenji Kanekiyo
, Shinobu Kitazume
, Yoshiki Yamaguchi
, Ichiro Matsuo
, Naoyuki Taniguchi

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

Original language	English
Pages (from-to)	27912-27926
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M113.474304
Publication status	Published - 27-09-2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.474304

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Korekane, H., Park, J. Y., Matsumoto, A., Nakajima, K., Takamatsu, S., Ohtsubo, K., Miyamoto, Y., Hanashima, S., Kanekiyo, K., Kitazume, S., Yamaguchi, Y., Matsuo, I., & Taniguchi, N. (2013). Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb). Journal of Biological Chemistry, 288(39), 27912-27926. https://doi.org/10.1074/jbc.M113.474304

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title = "Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)",

abstract = "Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.",

author = "Hiroaki Korekane and Park, \{Jong Yi\} and Akio Matsumoto and Kazuki Nakajima and Shinji Takamatsu and Kazuaki Ohtsubo and Yasuhide Miyamoto and Shinya Hanashima and Kenji Kanekiyo and Shinobu Kitazume and Yoshiki Yamaguchi and Ichiro Matsuo and Naoyuki Taniguchi",

year = "2013",

month = sep,

day = "27",

doi = "10.1074/jbc.M113.474304",

language = "English",

volume = "288",

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journal = "Journal of Biological Chemistry",

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Korekane, H, Park, JY, Matsumoto, A, Nakajima, K, Takamatsu, S, Ohtsubo, K, Miyamoto, Y, Hanashima, S, Kanekiyo, K, Kitazume, S, Yamaguchi, Y, Matsuo, I & Taniguchi, N 2013, 'Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)', Journal of Biological Chemistry, vol. 288, no. 39, pp. 27912-27926. https://doi.org/10.1074/jbc.M113.474304

TY - JOUR

T1 - Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

AU - Korekane, Hiroaki

AU - Park, Jong Yi

AU - Matsumoto, Akio

AU - Nakajima, Kazuki

AU - Takamatsu, Shinji

AU - Ohtsubo, Kazuaki

AU - Miyamoto, Yasuhide

AU - Hanashima, Shinya

AU - Kanekiyo, Kenji

AU - Kitazume, Shinobu

AU - Yamaguchi, Yoshiki

AU - Matsuo, Ichiro

AU - Taniguchi, Naoyuki

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

AB - Background: The regulatory mechanisms of glycosyltransferase activity are still poorly understood. Results: ENPP3 was identified as an inhibitory factor for N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) in Neuro2a cells. The underlying basis for this inhibition is the ENPP3-catalyzed hydrolysis of the nucleotide sugar donor substrate. Conclusion: ENPP3 is a regulator of glycosyltransferase activity. Significance: A novel regulatory system for the cellular glycosylation process is proposed.

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U2 - 10.1074/jbc.M113.474304

DO - 10.1074/jbc.M113.474304

M3 - Article

C2 - 23960081

AN - SCOPUS:84884733658

SN - 0021-9258

VL - 288

SP - 27912

EP - 27926

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

ER -

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb)

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