Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Masaaki Arai; Shigeru Amano; Akihide Ryo; Akiyuki Hada; Toru Wakatsuki; Masahiro Shuda; Nobuo Kondoh; Mikio Yamamoto

doi:10.1016/S0169-328X(03)00329-2

Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Masaaki Arai, Shigeru Amano, Akihide Ryo, Akiyuki Hada, Toru Wakatsuki, Masahiro Shuda, Nobuo Kondoh, Mikio Yamamoto

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	Molecular Brain Research
Volume	118
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(03)00329-2
Publication status	Published - 21-10-2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(03)00329-2

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title = "Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat",

abstract = "Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.",

author = "Masaaki Arai and Shigeru Amano and Akihide Ryo and Akiyuki Hada and Toru Wakatsuki and Masahiro Shuda and Nobuo Kondoh and Mikio Yamamoto",

note = "Funding Information: This work was supported by a grant-in aid for Science Research from the Japan Epilepsy Research Foundation.",

year = "2003",

month = oct,

day = "21",

doi = "10.1016/S0169-328X(03)00329-2",

language = "English",

volume = "118",

pages = "147--151",

journal = "Molecular Brain Research",

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TY - JOUR

T1 - Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

AU - Arai, Masaaki

AU - Amano, Shigeru

AU - Ryo, Akihide

AU - Hada, Akiyuki

AU - Wakatsuki, Toru

AU - Shuda, Masahiro

AU - Kondoh, Nobuo

AU - Yamamoto, Mikio

N1 - Funding Information: This work was supported by a grant-in aid for Science Research from the Japan Epilepsy Research Foundation.

PY - 2003/10/21

Y1 - 2003/10/21

N2 - Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.

AB - Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.

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U2 - 10.1016/S0169-328X(03)00329-2

DO - 10.1016/S0169-328X(03)00329-2

M3 - Article

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AN - SCOPUS:0141992065

SN - 0169-328X

VL - 118

SP - 147

EP - 151

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Abstract

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