TY - JOUR
T1 - Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat
AU - Arai, Masaaki
AU - Amano, Shigeru
AU - Ryo, Akihide
AU - Hada, Akiyuki
AU - Wakatsuki, Toru
AU - Shuda, Masahiro
AU - Kondoh, Nobuo
AU - Yamamoto, Mikio
N1 - Funding Information:
This work was supported by a grant-in aid for Science Research from the Japan Epilepsy Research Foundation.
PY - 2003/10/21
Y1 - 2003/10/21
N2 - Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.
AB - Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.
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U2 - 10.1016/S0169-328X(03)00329-2
DO - 10.1016/S0169-328X(03)00329-2
M3 - Article
C2 - 14559364
AN - SCOPUS:0141992065
SN - 0006-8993
VL - 118
SP - 147
EP - 151
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -