Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Masaaki Arai, Shigeru Amano, Akihide Ryo, Akiyuki Hada, Toru Wakatsuki, Masahiro Shuda, Nobuo Kondoh, Mikio Yamamoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalMolecular Brain Research
Volume118
Issue number1-2
DOIs
Publication statusPublished - 21-10-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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