TY - JOUR
T1 - Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population
AU - Koriyama, Hiroshi
AU - Nakagami, Hironori
AU - Katsuya, Tomohiro
AU - Sugimoto, Ken
AU - Yamashita, Hidetoshi
AU - Takami, Yoichi
AU - Maeda, Shiro
AU - Kubo, Michiaki
AU - Takahashi, Atsushi
AU - Nakamura, Yusuke
AU - Ogihara, Toshio
AU - Rakugi, Hiromi
AU - Kaneda, Yasufumi
AU - Morishita, Ryuichi
PY - 2010
Y1 - 2010
N2 - Aim: Peripheral arterial disease (PAD) is a common cause of cardiovascular morbidity and an independent predictor of cardiovascular mortality. However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals. Methods: We initially tested 222,285 single-nucleotide polymorphisms (SNPs). After the first screening in a panel of 195 PAD cases and 1,358 controls, 2,696 SNPs (1.2%) were further genotyped in the second screening using another panel of 699 PAD cases and 1540 controls. In both screenings, controls were subjects affected with some diseases other than PAD. Results: When analyzed in the combined panel, the strongest signal of PAD association was observed at rs1902341 in the intron of OSBPL10 (p = 4.7E-7 for trend test; OR = 1.31, 95% CI 1.18-1.46). Also, PAD was modestly associated at several other loci such as rs2554503 in CSMD1 (p = 5.7E-5; OR = 1.32, 95% CI 1.15-1.51) or rs235243 in VSP13D (p = 0.04; OR = 1.18, 95% CI 1.01-1.37). Conclusion: Our genome-wide exploration identified suggestive evidence of PAD association at the OSBPL10 locus. Because the association has not reached a genome-wide significant level, further replication study is warranted for verification in the Japanese population.
AB - Aim: Peripheral arterial disease (PAD) is a common cause of cardiovascular morbidity and an independent predictor of cardiovascular mortality. However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals. Methods: We initially tested 222,285 single-nucleotide polymorphisms (SNPs). After the first screening in a panel of 195 PAD cases and 1,358 controls, 2,696 SNPs (1.2%) were further genotyped in the second screening using another panel of 699 PAD cases and 1540 controls. In both screenings, controls were subjects affected with some diseases other than PAD. Results: When analyzed in the combined panel, the strongest signal of PAD association was observed at rs1902341 in the intron of OSBPL10 (p = 4.7E-7 for trend test; OR = 1.31, 95% CI 1.18-1.46). Also, PAD was modestly associated at several other loci such as rs2554503 in CSMD1 (p = 5.7E-5; OR = 1.32, 95% CI 1.15-1.51) or rs235243 in VSP13D (p = 0.04; OR = 1.18, 95% CI 1.01-1.37). Conclusion: Our genome-wide exploration identified suggestive evidence of PAD association at the OSBPL10 locus. Because the association has not reached a genome-wide significant level, further replication study is warranted for verification in the Japanese population.
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U2 - 10.5551/jat.4291
DO - 10.5551/jat.4291
M3 - Article
C2 - 20610895
AN - SCOPUS:78249283533
SN - 1340-3478
VL - 17
SP - 1054
EP - 1062
JO - Journal of atherosclerosis and thrombosis
JF - Journal of atherosclerosis and thrombosis
IS - 10
ER -