Identification of hippocampus-related candidate genes for Alzheimer's disease

Keiko Taguchi; Hidehisa D. Yamagata; Wangtao Zhong; Kouzin Kamino; Hiroyasu Akatsu; Ryuji Hata; Takayuki Yamamoto; Kenji Kosaka; Masatoshi Takeda; Ikuko Kondo; Tetsuro Miki

doi:10.1002/ana.20433

Identification of hippocampus-related candidate genes for Alzheimer's disease

Keiko Taguchi, Hidehisa D. Yamagata, Wangtao Zhong, Kouzin Kamino, Hiroyasu Akatsu, Ryuji Hata, Takayuki Yamamoto, Kenji Kosaka, Masatoshi Takeda, Ikuko Kondo, Tetsuro Miki

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36 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.

Original language	English
Pages (from-to)	585-588
Number of pages	4
Journal	Annals of Neurology
Volume	57
Issue number	4
DOIs	https://doi.org/10.1002/ana.20433
Publication status	Published - 01-04-2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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10.1002/ana.20433

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title = "Identification of hippocampus-related candidate genes for Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.",

author = "Keiko Taguchi and Yamagata, {Hidehisa D.} and Wangtao Zhong and Kouzin Kamino and Hiroyasu Akatsu and Ryuji Hata and Takayuki Yamamoto and Kenji Kosaka and Masatoshi Takeda and Ikuko Kondo and Tetsuro Miki",

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T1 - Identification of hippocampus-related candidate genes for Alzheimer's disease

AU - Taguchi, Keiko

AU - Yamagata, Hidehisa D.

AU - Zhong, Wangtao

AU - Kamino, Kouzin

AU - Akatsu, Hiroyasu

AU - Hata, Ryuji

AU - Yamamoto, Takayuki

AU - Kosaka, Kenji

AU - Takeda, Masatoshi

AU - Kondo, Ikuko

AU - Miki, Tetsuro

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.

AB - Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.

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Identification of hippocampus-related candidate genes for Alzheimer's disease

Abstract

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