Abstract
Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.
| Original language | English |
|---|---|
| Pages (from-to) | 585-588 |
| Number of pages | 4 |
| Journal | Annals of Neurology |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-04-2005 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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Identification of hippocampus-related candidate genes for Alzheimer's disease. / Taguchi, Keiko; Yamagata, Hidehisa D.; Zhong, Wangtao; Kamino, Kouzin; Akatsu, Hiroyasu; Hata, Ryuji; Yamamoto, Takayuki; Kosaka, Kenji; Takeda, Masatoshi; Kondo, Ikuko; Miki, Tetsuro.
In: Annals of Neurology, Vol. 57, No. 4, 01.04.2005, p. 585-588.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of hippocampus-related candidate genes for Alzheimer's disease
AU - Taguchi, Keiko
AU - Yamagata, Hidehisa D.
AU - Zhong, Wangtao
AU - Kamino, Kouzin
AU - Akatsu, Hiroyasu
AU - Hata, Ryuji
AU - Yamamoto, Takayuki
AU - Kosaka, Kenji
AU - Takeda, Masatoshi
AU - Kondo, Ikuko
AU - Miki, Tetsuro
PY - 2005/4/1
Y1 - 2005/4/1
N2 - Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.
AB - Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.
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UR - http://www.scopus.com/inward/citedby.url?scp=20144388360&partnerID=8YFLogxK
U2 - 10.1002/ana.20433
DO - 10.1002/ana.20433
M3 - Article
C2 - 15786443
AN - SCOPUS:20144388360
VL - 57
SP - 585
EP - 588
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 4
ER -