TY - JOUR
T1 - Identification of l-DOPA immunoreactivity in some neurons in the human mesencephalic region
T2 - a novel DOPA neuron group?
AU - Komori, K.
AU - Uesaka, S.
AU - Yamaoka, H.
AU - Fujita, K.
AU - Yamaoka, K.
AU - Naitoh, H.
AU - Kuroda, M.
AU - Karasawa, N.
AU - Ito, T.
AU - Kasahara, Y.
AU - Nagatsu, I.
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research, Ministry of Education, Science and Culture, Japan, and by a Grant-in-Aid from Fujita Health University, Japan.
PY - 1993/7/9
Y1 - 1993/7/9
N2 - The presence of l-3,4-dihydroxyphenylalanine (l-DOPA) immunoreactivity is reported for the first time in some neurons in the human mesencephalic region, using an immunohistochemical method with a newly raised, highly specific anti-l-DOPA antiserum. We have found many l-DOPA-positive/dopamine (DA)-positive and a few l-DOPA-positive/DA-negative cell bodies in dopaminergic regions in the midbrain. The present results suggest the existence of more than one neuronal group of l-DOPA in the human mesencephalon. l-DOPA in one group is an intermediate metabolite for decarboxylation to DA and in another group may exist as an endproduct. l-DOPA in the latter neurons could be a neuromodulator and/or neurotransmitter. Thus, we suggest that l-DOPA plays an important role besides being an intermediate of DA in the human mesencephalon.
AB - The presence of l-3,4-dihydroxyphenylalanine (l-DOPA) immunoreactivity is reported for the first time in some neurons in the human mesencephalic region, using an immunohistochemical method with a newly raised, highly specific anti-l-DOPA antiserum. We have found many l-DOPA-positive/dopamine (DA)-positive and a few l-DOPA-positive/DA-negative cell bodies in dopaminergic regions in the midbrain. The present results suggest the existence of more than one neuronal group of l-DOPA in the human mesencephalon. l-DOPA in one group is an intermediate metabolite for decarboxylation to DA and in another group may exist as an endproduct. l-DOPA in the latter neurons could be a neuromodulator and/or neurotransmitter. Thus, we suggest that l-DOPA plays an important role besides being an intermediate of DA in the human mesencephalon.
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U2 - 10.1016/0304-3940(93)90631-T
DO - 10.1016/0304-3940(93)90631-T
M3 - Article
C2 - 8233022
AN - SCOPUS:0027179673
SN - 0304-3940
VL - 157
SP - 13
EP - 16
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -