Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C.A. Spencer, Bryan Howie, Hin Tak Leung, Annette M. Hartmann, Hans Jürgen Möller, Derek W. Morris, Yong Yong Shi & 36 others Guo Yin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M. Quinn, Thomas G. Schulze, Nigel M. Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R. Sanders, Douglas F. Levinson, Pablo V. Gejman, Nancy G. Buccola, Bryan J. Mowry, Robert Freedman, Farooq Amin, Donald W. Black, Jeremy M. Silverman, William F. Byerley, C. Robert Cloninger, Sven Cichon, Markus M. Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J. Owen

Research output: Contribution to journalArticle

792 Citations (Scopus)

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

Original languageEnglish
Pages (from-to)1053-1055
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 01-09-2008

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Internal-External Control
Genome-Wide Association Study
Bipolar Disorder
Meta-Analysis
Schizophrenia
Genome
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201
O'Donovan, Michael C. ; Craddock, Nicholas ; Norton, Nadine ; Williams, Hywel ; Peirce, Timothy ; Moskvina, Valentina ; Nikolov, Ivan ; Hamshere, Marian ; Carroll, Liam ; Georgieva, Lyudmila ; Dwyer, Sarah ; Holmans, Peter ; Marchini, Jonathan L. ; Spencer, Chris C.A. ; Howie, Bryan ; Leung, Hin Tak ; Hartmann, Annette M. ; Möller, Hans Jürgen ; Morris, Derek W. ; Shi, Yong Yong ; Feng, Guo Yin ; Hoffmann, Per ; Propping, Peter ; Vasilescu, Catalina ; Maier, Wolfgang ; Rietschel, Marcella ; Zammit, Stanley ; Schumacher, Johannes ; Quinn, Emma M. ; Schulze, Thomas G. ; Williams, Nigel M. ; Giegling, Ina ; Iwata, Nakao ; Ikeda, Masashi ; Darvasi, Ariel ; Shifman, Sagiv ; He, Lin ; Duan, Jubao ; Sanders, Alan R. ; Levinson, Douglas F. ; Gejman, Pablo V. ; Buccola, Nancy G. ; Mowry, Bryan J. ; Freedman, Robert ; Amin, Farooq ; Black, Donald W. ; Silverman, Jeremy M. ; Byerley, William F. ; Cloninger, C. Robert ; Cichon, Sven ; Nöthen, Markus M. ; Gill, Michael ; Corvin, Aiden ; Rujescu, Dan ; Kirov, George ; Owen, Michael J. / Identification of loci associated with schizophrenia by genome-wide association and follow-up. In: Nature Genetics. 2008 ; Vol. 40, No. 9. pp. 1053-1055.
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O'Donovan, MC, Craddock, N, Norton, N, Williams, H, Peirce, T, Moskvina, V, Nikolov, I, Hamshere, M, Carroll, L, Georgieva, L, Dwyer, S, Holmans, P, Marchini, JL, Spencer, CCA, Howie, B, Leung, HT, Hartmann, AM, Möller, HJ, Morris, DW, Shi, YY, Feng, GY, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, EM, Schulze, TG, Williams, NM, Giegling, I, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, AR, Levinson, DF, Gejman, PV, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Cloninger, CR, Cichon, S, Nöthen, MM, Gill, M, Corvin, A, Rujescu, D, Kirov, G & Owen, MJ 2008, 'Identification of loci associated with schizophrenia by genome-wide association and follow-up', Nature Genetics, vol. 40, no. 9, pp. 1053-1055. https://doi.org/10.1038/ng.201

Identification of loci associated with schizophrenia by genome-wide association and follow-up. / O'Donovan, Michael C.; Craddock, Nicholas; Norton, Nadine; Williams, Hywel; Peirce, Timothy; Moskvina, Valentina; Nikolov, Ivan; Hamshere, Marian; Carroll, Liam; Georgieva, Lyudmila; Dwyer, Sarah; Holmans, Peter; Marchini, Jonathan L.; Spencer, Chris C.A.; Howie, Bryan; Leung, Hin Tak; Hartmann, Annette M.; Möller, Hans Jürgen; Morris, Derek W.; Shi, Yong Yong; Feng, Guo Yin; Hoffmann, Per; Propping, Peter; Vasilescu, Catalina; Maier, Wolfgang; Rietschel, Marcella; Zammit, Stanley; Schumacher, Johannes; Quinn, Emma M.; Schulze, Thomas G.; Williams, Nigel M.; Giegling, Ina; Iwata, Nakao; Ikeda, Masashi; Darvasi, Ariel; Shifman, Sagiv; He, Lin; Duan, Jubao; Sanders, Alan R.; Levinson, Douglas F.; Gejman, Pablo V.; Buccola, Nancy G.; Mowry, Bryan J.; Freedman, Robert; Amin, Farooq; Black, Donald W.; Silverman, Jeremy M.; Byerley, William F.; Cloninger, C. Robert; Cichon, Sven; Nöthen, Markus M.; Gill, Michael; Corvin, Aiden; Rujescu, Dan; Kirov, George; Owen, Michael J.

In: Nature Genetics, Vol. 40, No. 9, 01.09.2008, p. 1053-1055.

Research output: Contribution to journalArticle

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T1 - Identification of loci associated with schizophrenia by genome-wide association and follow-up

AU - O'Donovan, Michael C.

AU - Craddock, Nicholas

AU - Norton, Nadine

AU - Williams, Hywel

AU - Peirce, Timothy

AU - Moskvina, Valentina

AU - Nikolov, Ivan

AU - Hamshere, Marian

AU - Carroll, Liam

AU - Georgieva, Lyudmila

AU - Dwyer, Sarah

AU - Holmans, Peter

AU - Marchini, Jonathan L.

AU - Spencer, Chris C.A.

AU - Howie, Bryan

AU - Leung, Hin Tak

AU - Hartmann, Annette M.

AU - Möller, Hans Jürgen

AU - Morris, Derek W.

AU - Shi, Yong Yong

AU - Feng, Guo Yin

AU - Hoffmann, Per

AU - Propping, Peter

AU - Vasilescu, Catalina

AU - Maier, Wolfgang

AU - Rietschel, Marcella

AU - Zammit, Stanley

AU - Schumacher, Johannes

AU - Quinn, Emma M.

AU - Schulze, Thomas G.

AU - Williams, Nigel M.

AU - Giegling, Ina

AU - Iwata, Nakao

AU - Ikeda, Masashi

AU - Darvasi, Ariel

AU - Shifman, Sagiv

AU - He, Lin

AU - Duan, Jubao

AU - Sanders, Alan R.

AU - Levinson, Douglas F.

AU - Gejman, Pablo V.

AU - Buccola, Nancy G.

AU - Mowry, Bryan J.

AU - Freedman, Robert

AU - Amin, Farooq

AU - Black, Donald W.

AU - Silverman, Jeremy M.

AU - Byerley, William F.

AU - Cloninger, C. Robert

AU - Cichon, Sven

AU - Nöthen, Markus M.

AU - Gill, Michael

AU - Corvin, Aiden

AU - Rujescu, Dan

AU - Kirov, George

AU - Owen, Michael J.

PY - 2008/9/1

Y1 - 2008/9/1

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O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics. 2008 Sep 1;40(9):1053-1055. https://doi.org/10.1038/ng.201