Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael C. O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L. Marchini, Chris C.A. Spencer, Bryan Howie, Hin Tak Leung, Annette M. Hartmann, Hans Jürgen Möller, Derek W. Morris, Yong Yong ShiGuo Yin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M. Quinn, Thomas G. Schulze, Nigel M. Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R. Sanders, Douglas F. Levinson, Pablo V. Gejman, Nancy G. Buccola, Bryan J. Mowry, Robert Freedman, Farooq Amin, Donald W. Black, Jeremy M. Silverman, William F. Byerley, C. Robert Cloninger, Sven Cichon, Markus M. Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael J. Owen

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Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).

Original languageEnglish
Pages (from-to)1053-1055
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 01-09-2008

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All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H. T., Hartmann, A. M., Möller, H. J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201