Identification of plexin family molecules in mice

Toshiki Kameyama, Yasunori Murakami, Fumikazu Suto, Atsushi Kawakami, Shin Takagi, Tatsumi Hirata, Hajime Fujisawa

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1. Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins. Thus, we named these two proteins mouse plexin 2 and mouse plexin 3. We obtained mouse plexin 3 cDNA clones in which a part of protein-coding region was deleted. Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that, in the mouse, plexins comprise a molecular family (the plexin family).

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume226
Issue number2
DOIs
Publication statusPublished - 13-09-1996

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Molecules
Proteins
Complementary DNA
Amino Acid Motifs
plexin
Gene Library
Northern Blotting
Open Reading Frames
Cysteine
Brain
Screening
Membrane Proteins
Clone Cells
Amino Acids
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., & Fujisawa, H. (1996). Identification of plexin family molecules in mice. Biochemical and Biophysical Research Communications, 226(2), 396-402. https://doi.org/10.1006/bbrc.1996.1367
Kameyama, Toshiki ; Murakami, Yasunori ; Suto, Fumikazu ; Kawakami, Atsushi ; Takagi, Shin ; Hirata, Tatsumi ; Fujisawa, Hajime. / Identification of plexin family molecules in mice. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 226, No. 2. pp. 396-402.
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Kameyama, T, Murakami, Y, Suto, F, Kawakami, A, Takagi, S, Hirata, T & Fujisawa, H 1996, 'Identification of plexin family molecules in mice', Biochemical and Biophysical Research Communications, vol. 226, no. 2, pp. 396-402. https://doi.org/10.1006/bbrc.1996.1367

Identification of plexin family molecules in mice. / Kameyama, Toshiki; Murakami, Yasunori; Suto, Fumikazu; Kawakami, Atsushi; Takagi, Shin; Hirata, Tatsumi; Fujisawa, Hajime.

In: Biochemical and Biophysical Research Communications, Vol. 226, No. 2, 13.09.1996, p. 396-402.

Research output: Contribution to journalArticle

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