Identification of plexin family molecules in mice

Toshiki Kameyama, Yasunori Murakami, Fumikazu Suto, Atsushi Kawakami, Shin Takagi, Tatsumi Hirata, Hajime Fujisawa

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Abstract

By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1. Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins. Thus, we named these two proteins mouse plexin 2 and mouse plexin 3. We obtained mouse plexin 3 cDNA clones in which a part of protein-coding region was deleted. Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that, in the mouse, plexins comprise a molecular family (the plexin family).

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume226
Issue number2
DOIs
Publication statusPublished - 13-09-1996

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., & Fujisawa, H. (1996). Identification of plexin family molecules in mice. Biochemical and Biophysical Research Communications, 226(2), 396-402. https://doi.org/10.1006/bbrc.1996.1367