Identity of holmes positive bodies with electron microscopically demonstrable nucleolus-like bodies in neuronal cytoplasm

Yoshimitsu Katoh, Nobuo Shimizu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

By light microscopic observation of mouse brain stained by Holmes' silver method deeply stained cytoplasmic inclusion bodies were seen in almost all nerve cells of the locus coeruleus. Electron microscopy of tissue samples from floating Vibratome sections stained by Holmes' silver method demonstrated that the nucleolus-like bodies in the cytoplasm were densely impregnated with gold particles. Hence, it was confirmed that the cytoplasmic inclusion bodies of paraffin sections stained by Holmes' method are identical to the so-called nucleolus-like bodies seen in electron microscopic studies.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalBiotechnic and Histochemistry
Volume57
Issue number2
DOIs
Publication statusPublished - 1982

All Science Journal Classification (ASJC) codes

  • Histology
  • Medical Laboratory Technology

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