Idiopathic adulthood ductopenia

I. Nakano, Y. Fukuda, Y. Koyama, F. Urano, M. Yamada, Y. Katano, A. Marui, K. Imada, T. Hayakawa, M. Ito, Y. Yamashita, M. Imoto, Y. Nakanuma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


In 1981, a 26 year old man occasionally demonstrated elevated serum transaminase concentrations. He had no history of medication, or a personal or family history of jaundice, except for prolonged physiological jaundice as a neonate. Serum hepatitis B surface antigen, hepatitis C virus antibody and anti-mitochondrial antibody were absent. A wedge biopsy specimen revealed ductular proliferation, mild inflammation of the portal area and disappearance of bile ducts from 80% of the portal tracts. Serial sections demonstrated a vanishing bile duct. Endoscopic retrograde choledochopancreatography, portography and arteriography demonstrated no abnormalities. In 1994, the patient died of hepatic failure following a 12 year observation period. He was subsequently diagnosed with idiopathic adulthood ductopenia on the basis of the criteria proposed by Ludwig.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number4
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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