IgA-producing lymphoplasmacytic lymphoma carrying the chromosomal abnormality t(8;14)

Yuta Gotoh, Yumi Aoyama, Hiroko Tsunemine, Yuka Idei, Ayano Mori, Taiichi Kodaka, Sachiko Iba, Akihiro Tomita, Tomoo Itoh, Takayuki Takahashi

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1 Citation (Scopus)

Abstract

IgA-producing lymphoplasmacytic lymphoma (LPL) is rare and IgH/c-myc translocation is rare in LPL. This is the first report of a case of IgA-producing LPL carrying t(8;14). An 86-year-old woman presented inguinal and intra-abdominal lymph node swelling, and lytic bone lesions in the lumbar vertebrae. A diagnosis of IgA-producing LPL was immunohistochemically made by inguinal lymph node biopsy. The serum IgA level was 1,180 mg/dL, which was revealed to be composed of IgA-λ mono-clonal protein. Bone marrow chromosomal analysis demonstrated a complex abnormal karyotype, including t(8;14)(q24;q32), which was confirmed by FISH analysis. Abnormal lymphocytes positive for CD19, CD20, cyIgA, and cyλ were detected on flow cytometry analysis of marrow cells. Best supportive care was selected because of dementia and refractory urinary tract infection. Circulating lymphoplasmacytic cells with the same phenotype and karyotype were observed, and increased in num-ber. The aggressive clinical course, including lytic bone lesions, may have been due to IgH/c-myc translocation or the nature of IgA-producing LPL.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalJournal of Clinical and Experimental Hematopathology
Volume59
Issue number3
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • General Medicine

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