IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Koji Matsumoto, Toshiharu Yasugi, Akinori Oki, Takuma Fujii, Chisato Nagata, Souei Sekiya, Hiroshi Hoshiai, Yuji Taketani, Tadahito Kanda, Takashi Kawana, Hiroyuki Yoshikawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalCancer Letters
Volume231
Issue number2
DOIs
Publication statusPublished - 18-01-2006
Externally publishedYes

Fingerprint

Cervical Intraepithelial Neoplasia
Capsid
Immunoglobulin G
Antibodies
DNA
Antibody Formation
Cohort Studies
Serum

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Matsumoto, Koji ; Yasugi, Toshiharu ; Oki, Akinori ; Fujii, Takuma ; Nagata, Chisato ; Sekiya, Souei ; Hoshiai, Hiroshi ; Taketani, Yuji ; Kanda, Tadahito ; Kawana, Takashi ; Yoshikawa, Hiroyuki. / IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia. In: Cancer Letters. 2006 ; Vol. 231, No. 2. pp. 309-313.
@article{3c07693e1aed4e178de1e2fd8920bee5,
title = "IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia",
abstract = "To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.",
author = "Koji Matsumoto and Toshiharu Yasugi and Akinori Oki and Takuma Fujii and Chisato Nagata and Souei Sekiya and Hiroshi Hoshiai and Yuji Taketani and Tadahito Kanda and Takashi Kawana and Hiroyuki Yoshikawa",
year = "2006",
month = "1",
day = "18",
doi = "10.1016/j.canlet.2005.02.023",
language = "English",
volume = "231",
pages = "309--313",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Matsumoto, K, Yasugi, T, Oki, A, Fujii, T, Nagata, C, Sekiya, S, Hoshiai, H, Taketani, Y, Kanda, T, Kawana, T & Yoshikawa, H 2006, 'IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia', Cancer Letters, vol. 231, no. 2, pp. 309-313. https://doi.org/10.1016/j.canlet.2005.02.023

IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia. / Matsumoto, Koji; Yasugi, Toshiharu; Oki, Akinori; Fujii, Takuma; Nagata, Chisato; Sekiya, Souei; Hoshiai, Hiroshi; Taketani, Yuji; Kanda, Tadahito; Kawana, Takashi; Yoshikawa, Hiroyuki.

In: Cancer Letters, Vol. 231, No. 2, 18.01.2006, p. 309-313.

Research output: Contribution to journalArticle

TY - JOUR

T1 - IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

AU - Matsumoto, Koji

AU - Yasugi, Toshiharu

AU - Oki, Akinori

AU - Fujii, Takuma

AU - Nagata, Chisato

AU - Sekiya, Souei

AU - Hoshiai, Hiroshi

AU - Taketani, Yuji

AU - Kanda, Tadahito

AU - Kawana, Takashi

AU - Yoshikawa, Hiroyuki

PY - 2006/1/18

Y1 - 2006/1/18

N2 - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

AB - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

UR - http://www.scopus.com/inward/record.url?scp=29844441096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29844441096&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2005.02.023

DO - 10.1016/j.canlet.2005.02.023

M3 - Article

VL - 231

SP - 309

EP - 313

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -