IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Koji Matsumoto; Toshiharu Yasugi; Akinori Oki; Takuma Fujii; Chisato Nagata; Souei Sekiya; Hiroshi Hoshiai; Yuji Taketani; Tadahito Kanda; Takashi Kawana; Hiroyuki Yoshikawa

doi:10.1016/j.canlet.2005.02.023

IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Koji Matsumoto
, Toshiharu Yasugi
, Akinori Oki
, Takuma Fujii
, Chisato Nagata
, Souei Sekiya
, Hiroshi Hoshiai
, Yuji Taketani
, Tadahito Kanda
, Takashi Kawana
, Hiroyuki Yoshikawa

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

Original language	English
Pages (from-to)	309-313
Number of pages	5
Journal	Cancer Letters
Volume	231
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.02.023
Publication status	Published - 18-01-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2005.02.023

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title = "IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia",

abstract = "To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.",

author = "Koji Matsumoto and Toshiharu Yasugi and Akinori Oki and Takuma Fujii and Chisato Nagata and Souei Sekiya and Hiroshi Hoshiai and Yuji Taketani and Tadahito Kanda and Takashi Kawana and Hiroyuki Yoshikawa",

note = "Funding Information: We thank Graham R. Leggatt (Centre for Immunology and Cancer Research, University of Queensland, Australia) for helpful discussion. We are also grateful to all the women that participated in this study. This work was supported by the grant (12218102) from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2006",

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day = "18",

doi = "10.1016/j.canlet.2005.02.023",

language = "English",

volume = "231",

pages = "309--313",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

AU - Matsumoto, Koji

AU - Yasugi, Toshiharu

AU - Oki, Akinori

AU - Fujii, Takuma

AU - Nagata, Chisato

AU - Sekiya, Souei

AU - Hoshiai, Hiroshi

AU - Taketani, Yuji

AU - Kanda, Tadahito

AU - Kawana, Takashi

AU - Yoshikawa, Hiroyuki

N1 - Funding Information: We thank Graham R. Leggatt (Centre for Immunology and Cancer Research, University of Queensland, Australia) for helpful discussion. We are also grateful to all the women that participated in this study. This work was supported by the grant (12218102) from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2006/1/18

Y1 - 2006/1/18

N2 - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

AB - To identify the predictive markers for spontaneous regression of cervical intraepithelial neoplasia (CIN), we examined whether IgG antibody responses to common human papillomavirus (HPV) L1-capsids correlate with CIN regression. In a cohort study, a total of 116 Japanese women with CIN grade I/II were tested for cervical HPV DNA and serum IgG antibodies to HPV16/52/58/6 L1-capsids. Our data suggest that baseline IgG reactivities to HPV L1-capsids do not serve as a predictive marker of CIN regression, in contrast to histological CIN grades and HPV DNA status.

UR - https://www.scopus.com/pages/publications/29844441096

UR - https://www.scopus.com/pages/publications/29844441096#tab=citedBy

U2 - 10.1016/j.canlet.2005.02.023

DO - 10.1016/j.canlet.2005.02.023

M3 - Article

C2 - 16399232

AN - SCOPUS:29844441096

SN - 0304-3835

VL - 231

SP - 309

EP - 313

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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