IL4 from T follicular helper cells downregulates antitumor immunity

Hidekazu Shirota, Dennis M. Klinman, Shuku Ei Ito, Hiroyasu Ito, Masato Kubo, Chikashi Ishioka

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Immune cells constitute a large fraction of the tumor microenvironment and modulate tumor progression. Clinical data indicate that chronic inflammation is present at tumor sites and that IL4 in particular is upregulated. Here, we demonstrate that T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes. These findings suggest that IL4 from Tfh cells affects antitumor immunity and constitutes an attractive therapeutic target to reduce immunosuppression in the tumor microenvironment, and thus enhance the efficacy of cancer immunotherapy.

Original languageEnglish
Pages (from-to)61-71
Number of pages11
JournalCancer Immunology Research
Issue number1
Publication statusPublished - 01-2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cancer Research


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