TY - JOUR
T1 - Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo
AU - Teranishi, Masaaki
AU - Naganawa, Shinji
AU - Katayama, Naomi
AU - Sugiura, Makoto
AU - Nakata, Seiichi
AU - Sone, Michihiko
AU - Nakashima, Tsutomu
N1 - Funding Information:
This study was supported by research grants from the Ministry of Health, Labor, and Welfare and from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2009/12
Y1 - 2009/12
N2 - The objective of the present study was to investigate endolymphatic space images in patients with fluctuating hearing loss without vertigo, and to elucidate its underlying pathophysiology. Eight patients with fluctuating hearing loss without vertigo were included in this study. 3T MRI was taken, 24 h after intratympanic injection of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Electrocochleography and VEMP tests were performed to evaluate cochlear and vestibular functions. Endolymphatic hydrops were observed both in the cochlea and in the vestibule of all eight patients. Three patients out of six whose summating potential/action potential (SP/AP) ratio was recordable showed an elevation of SP/AP ratio. In the two patients with remarkable endolymphatic hydrops in the vestibule, VEMP was absent from the affected ear. In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with fluctuating hearing loss without vertigo.
AB - The objective of the present study was to investigate endolymphatic space images in patients with fluctuating hearing loss without vertigo, and to elucidate its underlying pathophysiology. Eight patients with fluctuating hearing loss without vertigo were included in this study. 3T MRI was taken, 24 h after intratympanic injection of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). Electrocochleography and VEMP tests were performed to evaluate cochlear and vestibular functions. Endolymphatic hydrops were observed both in the cochlea and in the vestibule of all eight patients. Three patients out of six whose summating potential/action potential (SP/AP) ratio was recordable showed an elevation of SP/AP ratio. In the two patients with remarkable endolymphatic hydrops in the vestibule, VEMP was absent from the affected ear. In conclusion, 3T MRI after intratympanic injection of Gd-DTPA revealed endolymphatic hydrops both in the cochlea and in the vestibule in the patients with fluctuating hearing loss without vertigo.
UR - http://www.scopus.com/inward/record.url?scp=70350574755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350574755&partnerID=8YFLogxK
U2 - 10.1007/s00405-009-0989-5
DO - 10.1007/s00405-009-0989-5
M3 - Article
C2 - 19455350
AN - SCOPUS:70350574755
SN - 0937-4477
VL - 266
SP - 1871
EP - 1877
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 12
ER -