Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis

Daisuke Ishikawa, Takafumi Ando, Osamu Watanabe, Kazuhiro Ishiguro, Osamu Maeda, Nobuyuki Miyake, Masanao Nakamura, Ryoji Miyahara, Naoki Omiya, Yoshiki Hirooka, Emad M. El-Omar, Hidemi Goto

Research output: Contribution to journalArticle

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Abstract

Background: Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.Methods: Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.Results: On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy.Conclusions: In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.

Original languageEnglish
Article number29
JournalBMC Gastroenterology
Volume11
DOIs
Publication statusPublished - 31-03-2011
Externally publishedYes

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Elasticity Imaging Techniques
Colonoscopy
Ulcerative Colitis
Therapeutics
Leukapheresis
Colectomy
Cyclosporine
Ulcer
Edema
Steroids

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Ishikawa, Daisuke ; Ando, Takafumi ; Watanabe, Osamu ; Ishiguro, Kazuhiro ; Maeda, Osamu ; Miyake, Nobuyuki ; Nakamura, Masanao ; Miyahara, Ryoji ; Omiya, Naoki ; Hirooka, Yoshiki ; El-Omar, Emad M. ; Goto, Hidemi. / Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis. In: BMC Gastroenterology. 2011 ; Vol. 11.
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title = "Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis",
abstract = "Background: Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.Methods: Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.Results: On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70{\%}) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57{\%}) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50{\%}) random-type patients required treatment with cyclosporine. Three of 10 (30{\%}) hard-type patients required colectomy.Conclusions: In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.",
author = "Daisuke Ishikawa and Takafumi Ando and Osamu Watanabe and Kazuhiro Ishiguro and Osamu Maeda and Nobuyuki Miyake and Masanao Nakamura and Ryoji Miyahara and Naoki Omiya and Yoshiki Hirooka and El-Omar, {Emad M.} and Hidemi Goto",
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Ishikawa, D, Ando, T, Watanabe, O, Ishiguro, K, Maeda, O, Miyake, N, Nakamura, M, Miyahara, R, Omiya, N, Hirooka, Y, El-Omar, EM & Goto, H 2011, 'Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis', BMC Gastroenterology, vol. 11, 29. https://doi.org/10.1186/1471-230X-11-29

Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis. / Ishikawa, Daisuke; Ando, Takafumi; Watanabe, Osamu; Ishiguro, Kazuhiro; Maeda, Osamu; Miyake, Nobuyuki; Nakamura, Masanao; Miyahara, Ryoji; Omiya, Naoki; Hirooka, Yoshiki; El-Omar, Emad M.; Goto, Hidemi.

In: BMC Gastroenterology, Vol. 11, 29, 31.03.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis

AU - Ishikawa, Daisuke

AU - Ando, Takafumi

AU - Watanabe, Osamu

AU - Ishiguro, Kazuhiro

AU - Maeda, Osamu

AU - Miyake, Nobuyuki

AU - Nakamura, Masanao

AU - Miyahara, Ryoji

AU - Omiya, Naoki

AU - Hirooka, Yoshiki

AU - El-Omar, Emad M.

AU - Goto, Hidemi

PY - 2011/3/31

Y1 - 2011/3/31

N2 - Background: Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.Methods: Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.Results: On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy.Conclusions: In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.

AB - Background: Real-time tissue sonoelastography (EG) is a new non-invasive technique that visualizes differences in tissue strain. We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity.Methods: Thirty-seven UC patients undergoing EG and colonoscopy were invited to enroll. EG findings were classified as normal, homogeneous, random, or hard, and colonoscopic findings as normal, mucosal edema and erosion, punched-out ulcer, and extensive mucosal abrasion. Clinical findings were evaluated using clinical activity index (CAI) scores for each patient at colonoscopy.Results: On EG, 10 cases were classified as normal, 11 as homogeneous, 6 as random, and 10 as hard. EG findings showed a significant correlation those of colonoscopy (p < 0.001). Seven of 10 (70%) normal-type patients were in the remission phase, while all 6 random-type patients were in the active phase. Among active-phase patients, 4 of 7 (57%) homogeneous-type patients responded to steroid or leukocytapheresis therapy, while 3 of 6 (50%) random-type patients required treatment with cyclosporine. Three of 10 (30%) hard-type patients required colectomy.Conclusions: In this small series, EG findings reflected colonoscopic findings and correlated with disease activity among patients with UC.

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