TY - JOUR
T1 - Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
AU - Moraga, Ana
AU - Gómez-Vallejo, Vanessa
AU - Cuartero, María Isabel
AU - Szczupak, Boguslaw
AU - San Sebastián, Eneko
AU - Markuerkiaga, Irati
AU - Pradillo, Jesús M.
AU - Higuchi, Makoto
AU - Llop, Jordi
AU - Moro, María Ángeles
AU - Martín, Abraham
AU - Lizasoain, Ignacio
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2015
Y1 - 2015
N2 - The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/-mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
AB - The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/-mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
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U2 - 10.1177/0271678X15627657
DO - 10.1177/0271678X15627657
M3 - Article
C2 - 26787106
AN - SCOPUS:84962419876
SN - 0271-678X
VL - 36
SP - 702
EP - 708
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 4
ER -