Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

Ana Moraga, Vanessa Gómez-Vallejo, María Isabel Cuartero, Boguslaw Szczupak, Eneko San Sebastián, Irati Markuerkiaga, Jesús M. Pradillo, Makoto Higuchi, Jordi Llop, María Ángeles Moro, Abraham Martín, Ignacio Lizasoain

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4-/-mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4-/- mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

Original languageEnglish
Pages (from-to)702-708
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number4
DOIs
Publication statusPublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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