Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella

Tetsushi Yoshikawa, K. Suzuki, S. Suga, E. Miyata, H. Yamamoto, T. Hosokawa, T. Kumagai, Y. Asano

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An 8 year old girl was admitted to hospital with the typical clinical features of Guillain-Barre syndrome (GBS) after recovering from varicella. Onset of the disease was just two weeks after the onset of varicella in her young sister. Examination of cerebrospinal fluid and nerve conduction studies showed typical findings of GBS. Although serum from both the patient and sister were analysed for autoantibodies to gangliosides and myelin P0 protein, IgM anti-GM1 antibody and anti-GD1b antibody were only detected in the patient. HLA DR haplotypes were quite different between the two subjects. This suggests that these autoantibodles may play an important role in the pathogenesis of GBS after varicella zoster virus infection.

Original languageEnglish
Pages (from-to)172-173
Number of pages2
JournalArchives of Disease in Childhood
Volume83
Issue number2
DOIs
Publication statusPublished - 14-09-2000

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Guillain-Barre Syndrome
Chickenpox
Gangliosides
Siblings
Anti-Idiotypic Antibodies
Myelin P0 Protein
Human Herpesvirus 3
Neural Conduction
HLA-DR Antigens
Virus Diseases
Autoantibodies
Haplotypes
Immunoglobulin M
Cerebrospinal Fluid
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yoshikawa, Tetsushi ; Suzuki, K. ; Suga, S. ; Miyata, E. ; Yamamoto, H. ; Hosokawa, T. ; Kumagai, T. ; Asano, Y. / Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella. In: Archives of Disease in Childhood. 2000 ; Vol. 83, No. 2. pp. 172-173.
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Yoshikawa, T, Suzuki, K, Suga, S, Miyata, E, Yamamoto, H, Hosokawa, T, Kumagai, T & Asano, Y 2000, 'Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella', Archives of Disease in Childhood, vol. 83, no. 2, pp. 172-173. https://doi.org/10.1136/adc.83.2.172

Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella. / Yoshikawa, Tetsushi; Suzuki, K.; Suga, S.; Miyata, E.; Yamamoto, H.; Hosokawa, T.; Kumagai, T.; Asano, Y.

In: Archives of Disease in Childhood, Vol. 83, No. 2, 14.09.2000, p. 172-173.

Research output: Contribution to journalArticle

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