Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella

T. Yoshikawa; K. Suzuki; S. Suga; E. Miyata; H. Yamamoto; T. Hosokawa; T. Kumagai; Y. Asano

doi:10.1136/adc.83.2.172

Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella

T. Yoshikawa, K. Suzuki, S. Suga, E. Miyata, H. Yamamoto, T. Hosokawa, T. Kumagai, Y. Asano

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16 Citations (Scopus)

Abstract

An 8 year old girl was admitted to hospital with the typical clinical features of Guillain-Barre syndrome (GBS) after recovering from varicella. Onset of the disease was just two weeks after the onset of varicella in her young sister. Examination of cerebrospinal fluid and nerve conduction studies showed typical findings of GBS. Although serum from both the patient and sister were analysed for autoantibodies to gangliosides and myelin P0 protein, IgM anti-GM1 antibody and anti-GD1b antibody were only detected in the patient. HLA DR haplotypes were quite different between the two subjects. This suggests that these autoantibodles may play an important role in the pathogenesis of GBS after varicella zoster virus infection.

Original language	English
Pages (from-to)	172-173
Number of pages	2
Journal	Archives of Disease in Childhood
Volume	83
Issue number	2
DOIs	https://doi.org/10.1136/adc.83.2.172
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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abstract = "An 8 year old girl was admitted to hospital with the typical clinical features of Guillain-Barre syndrome (GBS) after recovering from varicella. Onset of the disease was just two weeks after the onset of varicella in her young sister. Examination of cerebrospinal fluid and nerve conduction studies showed typical findings of GBS. Although serum from both the patient and sister were analysed for autoantibodies to gangliosides and myelin P0 protein, IgM anti-GM1 antibody and anti-GD1b antibody were only detected in the patient. HLA DR haplotypes were quite different between the two subjects. This suggests that these autoantibodles may play an important role in the pathogenesis of GBS after varicella zoster virus infection.",

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AU - Yoshikawa, T.

AU - Suzuki, K.

AU - Suga, S.

AU - Miyata, E.

AU - Yamamoto, H.

AU - Hosokawa, T.

AU - Kumagai, T.

AU - Asano, Y.

PY - 2000

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AB - An 8 year old girl was admitted to hospital with the typical clinical features of Guillain-Barre syndrome (GBS) after recovering from varicella. Onset of the disease was just two weeks after the onset of varicella in her young sister. Examination of cerebrospinal fluid and nerve conduction studies showed typical findings of GBS. Although serum from both the patient and sister were analysed for autoantibodies to gangliosides and myelin P0 protein, IgM anti-GM1 antibody and anti-GD1b antibody were only detected in the patient. HLA DR haplotypes were quite different between the two subjects. This suggests that these autoantibodles may play an important role in the pathogenesis of GBS after varicella zoster virus infection.

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Immune response to gangliosides in a case of Guillain - Barre syndrome after varicella

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