Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea

Kunio Tsujimura, Yuichi Obata, Yasue Matsudaira, Satoshi Ozeki, Osamu Taguchi, Keiko Nishida, Yuko Okanami, Yoshiki Akatsuka, Kiyotaka Kuzushima, Toshitada Takahashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mouse thymus-leukemia antigens (TL) are aberrantly expressed on T lymphomas in C57BL/6 (B6) and C3H/He (C3H) mice, while they are not expressed on normal T lymphocytes in these strains. When N-butyl-N-nitrosourea (NBU), a chemical carcinogen, was administered orally to B6 and C3H strains, lymphoma development was slower than in T3b-TL gene-transduced counterpart strains expressing TL ubiquitously as self-antigens, suggesting that anti-TL immunity may play a protective role. In addition, the development of lymphomas was slightly slower in C3H than in B6, which seems to be in accordance with the results of skin graft experiments indicating that both cellular and humoral immunities against TL were stronger in C3H than B6 mice. The interesting finding that B lymphomas derived from a T3b-TL transgenic strain (C3H background) expressing a very high level of TL were rejected in C3H, but not in H-2Kb transgenic mice (C3H background), raises the possibility that TL-specific effector T cell populations are eliminated and/or anergized to a certain extent by interacting with H-2Kb molecules.

Original languageEnglish
Pages (from-to)914-919
Number of pages6
JournalCancer Science
Volume95
Issue number11
DOIs
Publication statusPublished - 01-11-2004
Externally publishedYes

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N-nitrosobutylurea
Carcinogens
Immunity
Lymphoma
Inbred C3H Mouse
T-Lymphocytes
thymus-leukemia antigens
Autoantigens
Humoral Immunity
Cellular Immunity

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tsujimura, Kunio ; Obata, Yuichi ; Matsudaira, Yasue ; Ozeki, Satoshi ; Taguchi, Osamu ; Nishida, Keiko ; Okanami, Yuko ; Akatsuka, Yoshiki ; Kuzushima, Kiyotaka ; Takahashi, Toshitada. / Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea. In: Cancer Science. 2004 ; Vol. 95, No. 11. pp. 914-919.
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title = "Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea",
abstract = "Mouse thymus-leukemia antigens (TL) are aberrantly expressed on T lymphomas in C57BL/6 (B6) and C3H/He (C3H) mice, while they are not expressed on normal T lymphocytes in these strains. When N-butyl-N-nitrosourea (NBU), a chemical carcinogen, was administered orally to B6 and C3H strains, lymphoma development was slower than in T3b-TL gene-transduced counterpart strains expressing TL ubiquitously as self-antigens, suggesting that anti-TL immunity may play a protective role. In addition, the development of lymphomas was slightly slower in C3H than in B6, which seems to be in accordance with the results of skin graft experiments indicating that both cellular and humoral immunities against TL were stronger in C3H than B6 mice. The interesting finding that B lymphomas derived from a T3b-TL transgenic strain (C3H background) expressing a very high level of TL were rejected in C3H, but not in H-2Kb transgenic mice (C3H background), raises the possibility that TL-specific effector T cell populations are eliminated and/or anergized to a certain extent by interacting with H-2Kb molecules.",
author = "Kunio Tsujimura and Yuichi Obata and Yasue Matsudaira and Satoshi Ozeki and Osamu Taguchi and Keiko Nishida and Yuko Okanami and Yoshiki Akatsuka and Kiyotaka Kuzushima and Toshitada Takahashi",
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Tsujimura, K, Obata, Y, Matsudaira, Y, Ozeki, S, Taguchi, O, Nishida, K, Okanami, Y, Akatsuka, Y, Kuzushima, K & Takahashi, T 2004, 'Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea', Cancer Science, vol. 95, no. 11, pp. 914-919. https://doi.org/10.1111/j.1349-7006.2004.tb02202.x

Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea. / Tsujimura, Kunio; Obata, Yuichi; Matsudaira, Yasue; Ozeki, Satoshi; Taguchi, Osamu; Nishida, Keiko; Okanami, Yuko; Akatsuka, Yoshiki; Kuzushima, Kiyotaka; Takahashi, Toshitada.

In: Cancer Science, Vol. 95, No. 11, 01.11.2004, p. 914-919.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea

AU - Tsujimura, Kunio

AU - Obata, Yuichi

AU - Matsudaira, Yasue

AU - Ozeki, Satoshi

AU - Taguchi, Osamu

AU - Nishida, Keiko

AU - Okanami, Yuko

AU - Akatsuka, Yoshiki

AU - Kuzushima, Kiyotaka

AU - Takahashi, Toshitada

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Mouse thymus-leukemia antigens (TL) are aberrantly expressed on T lymphomas in C57BL/6 (B6) and C3H/He (C3H) mice, while they are not expressed on normal T lymphocytes in these strains. When N-butyl-N-nitrosourea (NBU), a chemical carcinogen, was administered orally to B6 and C3H strains, lymphoma development was slower than in T3b-TL gene-transduced counterpart strains expressing TL ubiquitously as self-antigens, suggesting that anti-TL immunity may play a protective role. In addition, the development of lymphomas was slightly slower in C3H than in B6, which seems to be in accordance with the results of skin graft experiments indicating that both cellular and humoral immunities against TL were stronger in C3H than B6 mice. The interesting finding that B lymphomas derived from a T3b-TL transgenic strain (C3H background) expressing a very high level of TL were rejected in C3H, but not in H-2Kb transgenic mice (C3H background), raises the possibility that TL-specific effector T cell populations are eliminated and/or anergized to a certain extent by interacting with H-2Kb molecules.

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