Immuno-wall lab-on-chip companion diagnostic devices for rapid and low-cost detection of mutant epidermal growth factor receptors (EGFR) from cytological samples in lung cancer patients

T. Kasama, T. Hase, N. Nishiwaki, N. Yogo, M. Sato, M. Kondo, N. Kaji, M. Tokeshi, Y. Hasegawa, Y. Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In the present study, we propose immuno-wall lab-on-a-chip companion diagnostic devices for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) such as erlotinib and gefitinib. The lysates of cytological samples including pleural effusion in lung cancer patients were successfully analyzed within 20 minutes. This is the first experiment demonstrating the detection of mutated EGFRs in the pleural effusion by microdevices. Our devices have a great potential to become the next generation companion diagnostic devices which overcome the problems of currently available methods.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages925-927
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 01-01-2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 25-10-201529-10-2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period25-10-1529-10-15

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Kasama, T., Hase, T., Nishiwaki, N., Yogo, N., Sato, M., Kondo, M., Kaji, N., Tokeshi, M., Hasegawa, Y., & Baba, Y. (2015). Immuno-wall lab-on-chip companion diagnostic devices for rapid and low-cost detection of mutant epidermal growth factor receptors (EGFR) from cytological samples in lung cancer patients. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 925-927). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.