Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas

K. Oda; K. Inada; R. Y. Osamura

doi:10.1016/S0344-0338(11)80159-7

Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas

K. Oda, K. Inada, R. Y. Osamura

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.

Original language	English
Pages (from-to)	626-628
Number of pages	3
Journal	Pathology Research and Practice
Volume	187
Issue number	5
DOIs	https://doi.org/10.1016/S0344-0338(11)80159-7
Publication status	Published - 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Cell Biology

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10.1016/S0344-0338(11)80159-7

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title = "Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas",

abstract = "Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.",

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doi = "10.1016/S0344-0338(11)80159-7",

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T1 - Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas

AU - Oda, K.

AU - Inada, K.

AU - Osamura, R. Y.

PY - 1991

Y1 - 1991

N2 - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.

AB - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.

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JO - Pathology Research and Practice

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Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas

Abstract

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