Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas

K. Oda, K. Inada, R. Y. Osamura

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Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.

Original languageEnglish
Pages (from-to)626-628
Number of pages3
JournalPathology Research and Practice
Issue number5
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology


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