Immunological abnormalities

Hidekata Yasuoka, Masataka Kuwana

Research output: Chapter in Book/Report/Conference proceedingChapter


The pathogenesis of Behçet's disease (BD) is still unclear. Both genetic and environmental factors contribute to the onset of BD, although immunological abnormalities are thought to play an important role. Genetics are responsible for autoinflammation and an underlying immunological condition, while the activation of innate and adaptive immune systems are triggered by environmental factors such as bacterial or viral infections. Underlying immunological abnormalities can lead to a unique expression profile of cytokines associated with Th1 or Th17 and induce both cytotoxicity and neutrophil-dependent inflammation, which are involved in the pathogenesis of BD.

Original languageEnglish
Title of host publicationBehçet's Disease
Subtitle of host publicationProgress in Recent Years and Unmet Needs for the Future
PublisherNova Science Publishers, Inc.
Number of pages15
ISBN (Electronic)9781634829410
ISBN (Print)9781634828932
Publication statusPublished - 01-07-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


Dive into the research topics of 'Immunological abnormalities'. Together they form a unique fingerprint.

Cite this