Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease

Takafumi Ando, Osamu Watanabe, Kazuo Nobata, Kazuhiro Ishiguro, Osamu Maeda, Daisuke Ishikawa, Motofusa Hasegawa, Shinya Kondo, Tsuyoshi Kato, Naoki Omiya, Yasumasa Niwa, Hidemi Goto

Research output: Contribution to journalArticle

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Abstract

Background/Aims: Ulcerative colitis (UC) mainly affects the colon and rectum, whereas the chronic inflammatory process in Crohn's disease (CD) can affect any part of the gastrointestinal tract. Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients. Methods: 26 patients each with UC, CD or functional dyspepsia (FD) underwent diagnostic upper gastrointestinal endoscopy, and biopsy specimens were obtained from the gastric antrum.The contents of interleukin (IL)-6 and IL-8 in the organ culture supernatants of antral mucosal tissues were measured with enzyme-linked immunosorbent assay. Results: Endoscopically abnormal findings in the stomach were more frequent in CD than in UC or FD patients. Mononuclear cell infiltration and IL-6 production in the gastric antrum did not significantly differ between UC and FD patients, but were higher in those with CD. There was no significant difference in neutrophil infiltration or IL-8 production between UC, CD, and FD patients. Conclusions: UC patients did not show the immunological abnormalities in the stomach seen in CD patients.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalDigestion
Volume77
Issue number3-4
DOIs
Publication statusPublished - 01-08-2008
Externally publishedYes

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Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
Stomach
Dyspepsia
Pyloric Antrum
Interleukin-8
Interleukin-6
Gastrointestinal Endoscopy
Neutrophil Infiltration
Organ Culture Techniques
Rectum
Gastrointestinal Tract
Colon
Mucous Membrane
Enzyme-Linked Immunosorbent Assay
Biopsy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Ando, T., Watanabe, O., Nobata, K., Ishiguro, K., Maeda, O., Ishikawa, D., ... Goto, H. (2008). Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease. Digestion, 77(3-4), 145-149. https://doi.org/10.1159/000140973
Ando, Takafumi ; Watanabe, Osamu ; Nobata, Kazuo ; Ishiguro, Kazuhiro ; Maeda, Osamu ; Ishikawa, Daisuke ; Hasegawa, Motofusa ; Kondo, Shinya ; Kato, Tsuyoshi ; Omiya, Naoki ; Niwa, Yasumasa ; Goto, Hidemi. / Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease. In: Digestion. 2008 ; Vol. 77, No. 3-4. pp. 145-149.
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Ando, T, Watanabe, O, Nobata, K, Ishiguro, K, Maeda, O, Ishikawa, D, Hasegawa, M, Kondo, S, Kato, T, Omiya, N, Niwa, Y & Goto, H 2008, 'Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease', Digestion, vol. 77, no. 3-4, pp. 145-149. https://doi.org/10.1159/000140973

Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease. / Ando, Takafumi; Watanabe, Osamu; Nobata, Kazuo; Ishiguro, Kazuhiro; Maeda, Osamu; Ishikawa, Daisuke; Hasegawa, Motofusa; Kondo, Shinya; Kato, Tsuyoshi; Omiya, Naoki; Niwa, Yasumasa; Goto, Hidemi.

In: Digestion, Vol. 77, No. 3-4, 01.08.2008, p. 145-149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunological status of the stomach in inflammatory bowel disease - Comparison between ulcerative colitis and Crohn's disease

AU - Ando, Takafumi

AU - Watanabe, Osamu

AU - Nobata, Kazuo

AU - Ishiguro, Kazuhiro

AU - Maeda, Osamu

AU - Ishikawa, Daisuke

AU - Hasegawa, Motofusa

AU - Kondo, Shinya

AU - Kato, Tsuyoshi

AU - Omiya, Naoki

AU - Niwa, Yasumasa

AU - Goto, Hidemi

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Background/Aims: Ulcerative colitis (UC) mainly affects the colon and rectum, whereas the chronic inflammatory process in Crohn's disease (CD) can affect any part of the gastrointestinal tract. Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients. Methods: 26 patients each with UC, CD or functional dyspepsia (FD) underwent diagnostic upper gastrointestinal endoscopy, and biopsy specimens were obtained from the gastric antrum.The contents of interleukin (IL)-6 and IL-8 in the organ culture supernatants of antral mucosal tissues were measured with enzyme-linked immunosorbent assay. Results: Endoscopically abnormal findings in the stomach were more frequent in CD than in UC or FD patients. Mononuclear cell infiltration and IL-6 production in the gastric antrum did not significantly differ between UC and FD patients, but were higher in those with CD. There was no significant difference in neutrophil infiltration or IL-8 production between UC, CD, and FD patients. Conclusions: UC patients did not show the immunological abnormalities in the stomach seen in CD patients.

AB - Background/Aims: Ulcerative colitis (UC) mainly affects the colon and rectum, whereas the chronic inflammatory process in Crohn's disease (CD) can affect any part of the gastrointestinal tract. Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients. Methods: 26 patients each with UC, CD or functional dyspepsia (FD) underwent diagnostic upper gastrointestinal endoscopy, and biopsy specimens were obtained from the gastric antrum.The contents of interleukin (IL)-6 and IL-8 in the organ culture supernatants of antral mucosal tissues were measured with enzyme-linked immunosorbent assay. Results: Endoscopically abnormal findings in the stomach were more frequent in CD than in UC or FD patients. Mononuclear cell infiltration and IL-6 production in the gastric antrum did not significantly differ between UC and FD patients, but were higher in those with CD. There was no significant difference in neutrophil infiltration or IL-8 production between UC, CD, and FD patients. Conclusions: UC patients did not show the immunological abnormalities in the stomach seen in CD patients.

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