Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD

Harumi Kato, Kazuhito Yamamoto, Takeshi Kodaira, Yusuke Higuchi, Hideyuki Yamamoto, Toko Saito, Hirofumi Taji, Yasushi Yatabe, Shigeo Nakamura, Tomohiro Kinoshita

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Immunophenotype is an important prognostic factor for childhood and adult T-cell acute lymphoblastic leukemia. However, immunophenotypic data from adult patients with T-cell lymphoblastic lymphoma (T-LBL) are scarcely available. Methods: Subjects were unselected adult patients with T-LBL who were treated with intensive chemotherapy. Immunophenotyping of tumor cells was performed according to standard techniques. Results: A total of eight patients with a median age of 31 years were analyzed who received hyper-CVAD treatment for LBL. Immunophenotypic analysis showed that the most common tumor type was cortical T-cell type [early T (n = 2), cortical T (n = 4), and medullary T (n = 2)]. Two patients diagnosed with early T-cell type had early disease progression. Conclusions: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalHematology
Volume23
Issue number2
DOIs
Publication statusPublished - 07-02-2018

All Science Journal Classification (ASJC) codes

  • Hematology

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