Impact of adiponectin and leptin on long-term adverse events in Japanese patients with acute myocardial infarction: Results from the nagoya acute myocardial infarction study (NAMIS)

Yasuhiro Morita, Kengo Maeda, Takahisa Kondo, Hideki Ishii, Kyoko Matsudaira, Naoki Okumura, Hirotsugu Mitsuhashi, Rei Shibata, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background: Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear. Methods and Results: This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33-3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43-0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45-0.76), P<0.001, respectively]. The leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up in a multivariable analysis [adjusted hazard ratio 0.60 (95% CI 0.43-0.83), P=0.002]. Conclusions: Higher adiponectin and lower leptin levels are associated with a high incidence of adverse events in Japanese patients after AMI, and the leptin to adiponectin ratio independently predicts prognosis after AMI.

Original languageEnglish
Pages (from-to)2778-2785
Number of pages8
JournalCirculation Journal
Volume77
Issue number11
DOIs
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Impact of adiponectin and leptin on long-term adverse events in Japanese patients with acute myocardial infarction: Results from the nagoya acute myocardial infarction study (NAMIS)'. Together they form a unique fingerprint.

Cite this