Impact of adipose tissue composition on cardiovascular risk assessment in patients with stable coronary artery disease

Ayako Kunimura, Hideki Ishii, Tadayuki Uetani, Kazuhiro Harada, Kenshi Hirayama, Shingo Harata, Yohei Shibata, Kazuhiro Kawashima, Yusaku Shimbo, Yohei Takayama, Yosuke Tatami, Toshiki Kawamiya, Naohiro Osugi, Tomoyuki Ota, Dai Yamamoto, Naoki Okumura, Susumu Suzuki, Tetsuya Amano, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background and aims Visceral adipose tissue (VAT), unlike subcutaneous adipose tissue (SAT), is highly correlated with cardiovascular risk factors. This study aimed to evaluate the predictive value of adipose tissue composition, as measured by computed tomography, for cardiovascular events in patients with stable coronary artery disease. Methods 357 consecutive patients who underwent 64-slice computed tomography and elective percutaneous coronary intervention (PCI) were recruited. The ratio of visceral to subcutaneous adipose tissue (VAT/SAT) was calculated. Patients were divided into three groups in accordance with VAT/SAT (low VAT/SAT, <0.55 [<25th percentile]; moderate VAT/SAT, 0.55–1.03 [25th–75th percentile]; high VAT/SAT, ≥1.03 [≥75th percentile]). The investigated risk factors were hypertension, hyperglycaemia, and dyslipidaemia. We analysed the incidence of major adverse cardiovascular events (MACE), defined as the composite of cardiac death, myocardial infarction, and any revascularization. Results The rate of patients with two or more concomitant risk factors was significantly higher in the high VAT/SAT group (p = 0.006). During 1480 person-years, 109 events were documented. There was a significant association between the incidence of MACE and VAT/SAT, with the worst event-free survival rate in the high VAT/SAT group (log-rank, p = 0.01). In Cox analysis, the hazard ratio of high VAT/SAT for MACE was 2.72 (95% confidence interval 1.04–7.09, p = 0.04) compared with the low VAT/SAT after adjustment for confounding factors. Conclusions Increased VAT/SAT is independently associated with the incidence of MACE, indicating that adipose tissue composition is a useful predictor of cardiovascular outcome, after elective PCI.

Original languageEnglish
Pages (from-to)206-212
Number of pages7
Publication statusPublished - 01-08-2016

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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