Impact of airflow limitation on carotid atherosclerosis in coronary artery disease patients

Mohammad Shoaib Hamrah, Susumu Suzuki, Hideki Ishii, Yohei Shibata, Yosuke Tatami, Naohiro Osugi, Tomoyuki Ota, Yoshihiro Kawamura, Akihito Tanaka, Hiromichi Aso, Kyosuke Takeshita, Junichi Sakamoto, Yoshinori Hasegawa, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Both airflow limitation and smoking are established cardiovascular risk factors. However, their interaction as risk factors for the development of atherosclerosis in coronary artery disease patients remains unclear. Objectives: To evaluate the effect of the interaction between airflow limitation and smoking status on the severity of carotid atherosclerosis. Methods: We categorized the 234 enrolled patients with coronary artery disease into four groups: never-smokers with normal pulmonary function (group A), never-smokers with airflow limitation (group B), ever-smokers with normal pulmonary function (group C), and ever-smokers with airflow limitation (group D). Results: The prevalence of airflow limitation in the enrolled patients was 23.1% (ever-smokers: 15.8%, never-smokers: 7.3%). The prevalence of severe carotid atherosclerosis was 28.2, 29.4, 41.3, and 45.9%, respectively, in the four groups (group D vs. group A, p = 0.035). Even after multivariate adjusting for confounding factors, ever-smokers with airflow limitation were independently associated with severe carotid atherosclerosis (odds ratio 2.89, 95% confidence interval, 1.19-7.00, p = 0.019). Conclusions: Ever-smokers with airflow limitation were significantly associated with severe carotid atherosclerosis among patients with coronary artery disease. These findings also provide additional insight into the correlation between airflow limitation and poor cardiovascular clinical outcomes.

Original languageEnglish
Pages (from-to)322-328
Number of pages7
Issue number4
Publication statusPublished - 21-04-2015

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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